3f2r: Difference between revisions

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<StructureSection load='3f2r' size='340' side='right'caption='[[3f2r]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
<StructureSection load='3f2r' size='340' side='right'caption='[[3f2r]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3f2r]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F2R OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3F2R FirstGlance]. <br>
<table><tr><td colspan='2'>[[3f2r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F2R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F2R FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HC6:(2S,2S)-2,2-BIPHENYL-4,4-DIYLBIS(2-HYDROXY-4,4-DIMETHYLMORPHOLIN-4-IUM)'>HC6</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3f2s|3f2s]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HC6:(2S,2S)-2,2-BIPHENYL-4,4-DIYLBIS(2-HYDROXY-4,4-DIMETHYLMORPHOLIN-4-IUM)'>HC6</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CHKA, CHK, CKI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f2r OCA], [https://pdbe.org/3f2r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f2r RCSB], [https://www.ebi.ac.uk/pdbsum/3f2r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f2r ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Choline_kinase Choline kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.32 2.7.1.32] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3f2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f2r OCA], [http://pdbe.org/3f2r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3f2r RCSB], [http://www.ebi.ac.uk/pdbsum/3f2r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3f2r ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CHKA_HUMAN CHKA_HUMAN]] Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.<ref>PMID:19915674</ref>
[https://www.uniprot.org/uniprot/CHKA_HUMAN CHKA_HUMAN] Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.<ref>PMID:19915674</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Choline kinase]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith CH]]
[[Category: Bochkarev, A]]
[[Category: Bochkarev A]]
[[Category: Bountra, C]]
[[Category: Bountra C]]
[[Category: Edwards, A M]]
[[Category: Edwards AM]]
[[Category: Hong, B]]
[[Category: Hong B]]
[[Category: MacKenzie, F]]
[[Category: MacKenzie F]]
[[Category: Park, H]]
[[Category: Park H]]
[[Category: Rabeh, W M]]
[[Category: Rabeh WM]]
[[Category: Structural genomic]]
[[Category: Tempel W]]
[[Category: Tempel, W]]
[[Category: Weigelt J]]
[[Category: Weigelt, J]]
[[Category: Alternative splicing]]
[[Category: Cytoplasm]]
[[Category: Hemicholinium-3]]
[[Category: Kinase]]
[[Category: Non-protein kinase]]
[[Category: Sgc]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/3f2r"