3g3m: Difference between revisions

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<StructureSection load='3g3m' size='340' side='right'caption='[[3g3m]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
<StructureSection load='3g3m' size='340' side='right'caption='[[3g3m]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3g3m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G3M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G3M FirstGlance]. <br>
<table><tr><td colspan='2'>[[3g3m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G3M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G3M FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5FU:5-FLUORO-URIDINE-5-MONOPHOSPHATE'>5FU</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5FU:5-FLUORO-URIDINE-5-MONOPHOSPHATE'>5FU</scene>, <scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3g3d|3g3d]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gi&#124;13960142, OK/SW-cl.21, UMPS ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g3m OCA], [https://pdbe.org/3g3m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g3m RCSB], [https://www.ebi.ac.uk/pdbsum/3g3m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g3m ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g3m OCA], [https://pdbe.org/3g3m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g3m RCSB], [https://www.ebi.ac.uk/pdbsum/3g3m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g3m ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[https://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN]] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[https://omim.org/entry/258900 258900]]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref>
[https://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[https://omim.org/entry/258900 258900]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref>  
== Function ==
[https://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Orotidine-5'-phosphate decarboxylase]]
[[Category: Bello AM]]
[[Category: Bello, A M]]
[[Category: Kotra LP]]
[[Category: Kotra, L P]]
[[Category: Liu Y]]
[[Category: Liu, Y]]
[[Category: Pai EF]]
[[Category: Pai, E F]]
[[Category: Poduch E]]
[[Category: Poduch, E]]
[[Category: Tang HL]]
[[Category: Tang, H L]]
[[Category: 5-fluoro-6-iodo-ump]]
[[Category: Alternative splicing]]
[[Category: C-terminal domain]]
[[Category: Decarboxylase]]
[[Category: Disease mutation]]
[[Category: Glycosyltransferase]]
[[Category: Lyase]]
[[Category: Multifunctional enzyme]]
[[Category: Orotidine 5'-monophosphate decarboxylase]]
[[Category: Phosphoprotein]]
[[Category: Polymorphism]]
[[Category: Pyrimidine biosynthesis]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/3g3m"