3g5m: Difference between revisions

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<StructureSection load='3g5m' size='340' side='right'caption='[[3g5m]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
<StructureSection load='3g5m' size='340' side='right'caption='[[3g5m]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3g5m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G5M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G5M FirstGlance]. <br>
<table><tr><td colspan='2'>[[3g5m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G5M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G5M FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=XM5:6-METHOXY-9-METHYL[1,3]DIOXOLO[4,5-H]QUINOLIN-8(9H)-ONE'>XM5</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.84&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NQO2, NMOR2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=XM5:6-METHOXY-9-METHYL[1,3]DIOXOLO[4,5-H]QUINOLIN-8(9H)-ONE'>XM5</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Ribosyldihydronicotinamide_dehydrogenase_(quinone) Ribosyldihydronicotinamide dehydrogenase (quinone)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.99.2 1.10.99.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g5m OCA], [https://pdbe.org/3g5m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g5m RCSB], [https://www.ebi.ac.uk/pdbsum/3g5m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g5m ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g5m OCA], [https://pdbe.org/3g5m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g5m RCSB], [https://www.ebi.ac.uk/pdbsum/3g5m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g5m ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN]] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>
[https://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Cushman, M]]
[[Category: Cushman M]]
[[Category: Maiti, A]]
[[Category: Maiti A]]
[[Category: Marler, L]]
[[Category: Marler L]]
[[Category: Mesecar, A D]]
[[Category: Mesecar AD]]
[[Category: Pegan, S D]]
[[Category: Pegan SD]]
[[Category: Pezzuto, J M]]
[[Category: Pezzuto JM]]
[[Category: Sturdy, M]]
[[Category: Sturdy M]]
[[Category: Casimiroin]]
[[Category: Cytoplasm]]
[[Category: Fad]]
[[Category: Flavoprotein]]
[[Category: Metal-binding]]
[[Category: Nq02]]
[[Category: Oxidoreductase]]
[[Category: Phosphoprotein]]
[[Category: Polymorphism]]
[[Category: Qr2]]
[[Category: Zinc]]
Retrieved from "https://proteopedia.org/3g5m"