3goc: Difference between revisions

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<StructureSection load='3goc' size='340' side='right'caption='[[3goc]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='3goc' size='340' side='right'caption='[[3goc]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3goc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Straw Straw]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GOC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GOC FirstGlance]. <br>
<table><tr><td colspan='2'>[[3goc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_avermitilis_MA-4680_=_NBRC_14893 Streptomyces avermitilis MA-4680 = NBRC 14893]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GOC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GOC FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=YES:3-(2-HYDROXYETHYL)-2,2-BIS(HYDROXYMETHYL)PENTANE-1,5-DIOL'>YES</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=YES:3-(2-HYDROXYETHYL)-2,2-BIS(HYDROXYMETHYL)PENTANE-1,5-DIOL'>YES</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">nfi ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=227882 STRAW])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Deoxyribonuclease_V Deoxyribonuclease V], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.21.7 3.1.21.7] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3goc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3goc OCA], [https://pdbe.org/3goc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3goc RCSB], [https://www.ebi.ac.uk/pdbsum/3goc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3goc ProSAT], [https://www.topsan.org/Proteins/NESGC/3goc TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3goc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3goc OCA], [https://pdbe.org/3goc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3goc RCSB], [https://www.ebi.ac.uk/pdbsum/3goc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3goc ProSAT], [https://www.topsan.org/Proteins/NESGC/3goc TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/NFI_STRAW NFI_STRAW]] DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA (By similarity).[HAMAP-Rule:MF_00801]  
[https://www.uniprot.org/uniprot/NFI_STRAW NFI_STRAW] DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA (By similarity).[HAMAP-Rule:MF_00801]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Deoxyribonuclease V]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Straw]]
[[Category: Streptomyces avermitilis MA-4680 = NBRC 14893]]
[[Category: Abashidze, M]]
[[Category: Abashidze M]]
[[Category: Acton, T B]]
[[Category: Acton TB]]
[[Category: Chen, C X]]
[[Category: Chen CX]]
[[Category: Cunningham, K]]
[[Category: Cunningham K]]
[[Category: Everett, J K]]
[[Category: Everett JK]]
[[Category: Fang, F]]
[[Category: Fang F]]
[[Category: Forouhar, F]]
[[Category: Forouhar F]]
[[Category: Hunt, J F]]
[[Category: Hunt JF]]
[[Category: Hussain, M]]
[[Category: Hussain M]]
[[Category: Ma, L]]
[[Category: Ma L]]
[[Category: Montelione, G T]]
[[Category: Montelione GT]]
[[Category: Structural genomic]]
[[Category: Nair R]]
[[Category: Nair, R]]
[[Category: Owens L]]
[[Category: Owens, L]]
[[Category: Rost B]]
[[Category: Rost, B]]
[[Category: Seetharaman J]]
[[Category: Seetharaman, J]]
[[Category: Tong L]]
[[Category: Tong, L]]
[[Category: Xiao R]]
[[Category: Xiao, R]]
[[Category: Alpha-beta protein]]
[[Category: Dna damage]]
[[Category: Dna repair]]
[[Category: Endonuclease]]
[[Category: Hydrolase]]
[[Category: Magnesium]]
[[Category: Nesg]]
[[Category: Nuclease]]
[[Category: PSI, Protein structure initiative]]

Revision as of 07:08, 6 September 2023

Crystal structure of the Endonuclease V (SAV1684) from Streptomyces avermitilis. Northeast Structural Genomics Consortium Target SvR196

3goc, resolution 1.60Å

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