3ik7: Difference between revisions

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<StructureSection load='3ik7' size='340' side='right'caption='[[3ik7]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
<StructureSection load='3ik7' size='340' side='right'caption='[[3ik7]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3ik7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IK7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IK7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3ik7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IK7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IK7 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOB:(S)-2-AMINO-5-((R)-1-(CARBOXYMETHYLAMINO)-3-((3S,4R)-1,4-DIHYDROXYNONAN-3-YLTHIO)-1-OXOPROPAN-2-YLAMINO)-5-OXOPENTANOIC+ACID'>BOB</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.97&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ik9|3ik9]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOB:(S)-2-AMINO-5-((R)-1-(CARBOXYMETHYLAMINO)-3-((3S,4R)-1,4-DIHYDROXYNONAN-3-YLTHIO)-1-OXOPROPAN-2-YLAMINO)-5-OXOPENTANOIC+ACID'>BOB</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GSTA4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ik7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ik7 OCA], [https://pdbe.org/3ik7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ik7 RCSB], [https://www.ebi.ac.uk/pdbsum/3ik7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ik7 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ik7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ik7 OCA], [https://pdbe.org/3ik7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ik7 RCSB], [https://www.ebi.ac.uk/pdbsum/3ik7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ik7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/GSTA4_HUMAN GSTA4_HUMAN]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4-hydroxynonenal (4-HNE).<ref>PMID:10329152</ref> <ref>PMID:20085333</ref>
[https://www.uniprot.org/uniprot/GSTA4_HUMAN GSTA4_HUMAN] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4-hydroxynonenal (4-HNE).<ref>PMID:10329152</ref> <ref>PMID:20085333</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Glutathione transferase]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Atkins, W M]]
[[Category: Atkins WM]]
[[Category: Balogh, L M]]
[[Category: Balogh LM]]
[[Category: Stenkamp, R E]]
[[Category: Le Trong I]]
[[Category: Trong, I Le]]
[[Category: Stenkamp RE]]
[[Category: Cytoplasm]]
[[Category: Enzyme]]
[[Category: Human gst a4-4]]
[[Category: Polymorphism]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/3ik7"