3ioi: Difference between revisions
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<StructureSection load='3ioi' size='340' side='right'caption='[[3ioi]], [[Resolution|resolution]] 1.45Å' scene=''> | <StructureSection load='3ioi' size='340' side='right'caption='[[3ioi]], [[Resolution|resolution]] 1.45Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3ioi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3ioi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IOI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IOI FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1GW:5-(2-FORMYLTHIEN-5-YL)-URIDINE-5-DIPHOSPHATE-ALPHA-D-GALACTOSE'>1GW</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1GW:5-(2-FORMYLTHIEN-5-YL)-URIDINE-5-DIPHOSPHATE-ALPHA-D-GALACTOSE'>1GW</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ioi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ioi OCA], [https://pdbe.org/3ioi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ioi RCSB], [https://www.ebi.ac.uk/pdbsum/3ioi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ioi ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ioi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ioi OCA], [https://pdbe.org/3ioi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ioi RCSB], [https://www.ebi.ac.uk/pdbsum/3ioi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ioi ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity. | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Jorgensen | [[Category: Jorgensen R]] | ||
[[Category: Palcic | [[Category: Palcic MM]] | ||
[[Category: Pesnot | [[Category: Pesnot T]] | ||
[[Category: Wagner | [[Category: Wagner GK]] | ||
Latest revision as of 07:54, 6 September 2023
Crystal structure of the Fucosylgalactoside alpha N-acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with a novel UDP-Gal derived inhibitor (1GW)
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