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==Crystal structure of dimeric abscisic acid (ABA) receptor pyrabactin resistance 1 (PYR1) with ABA-bound closed-lid and ABA-free open-lid subunits==
==Crystal structure of dimeric abscisic acid (ABA) receptor pyrabactin resistance 1 (PYR1) with ABA-bound closed-lid and ABA-free open-lid subunits==
<StructureSection load='3k3k' size='340' side='right' caption='[[3k3k]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='3k3k' size='340' side='right'caption='[[3k3k]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3k3k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K3K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K3K FirstGlance]. <br>
<table><tr><td colspan='2'>[[3k3k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K3K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K3K FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A8S:(2Z,4E)-5-[(1S)-1-HYDROXY-2,6,6-TRIMETHYL-4-OXOCYCLOHEX-2-EN-1-YL]-3-METHYLPENTA-2,4-DIENOIC+ACID'>A8S</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AT4g17870, PYR1, T6K21.50 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A8S:(2Z,4E)-5-[(1S)-1-HYDROXY-2,6,6-TRIMETHYL-4-OXOCYCLOHEX-2-EN-1-YL]-3-METHYLPENTA-2,4-DIENOIC+ACID'>A8S</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k3k OCA], [http://pdbe.org/3k3k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3k3k RCSB], [http://www.ebi.ac.uk/pdbsum/3k3k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3k3k ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k3k OCA], [https://pdbe.org/3k3k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k3k RCSB], [https://www.ebi.ac.uk/pdbsum/3k3k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k3k ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PYR1_ARATH PYR1_ARATH]] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.<ref>PMID:19624469</ref> <ref>PMID:19407142</ref> <ref>PMID:19769575</ref>
[https://www.uniprot.org/uniprot/PYR1_ARATH PYR1_ARATH] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.<ref>PMID:19624469</ref> <ref>PMID:19407142</ref> <ref>PMID:19769575</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[Abscisic acid receptor|Abscisic acid receptor]]
*[[Abscisic acid receptor|Abscisic acid receptor]]
*[[PYR/PYL/RCAR family of ABA receptors|PYR/PYL/RCAR family of ABA receptors]]
*[[Abscisic acid receptor 3D structures|Abscisic acid receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Arath]]
[[Category: Arabidopsis thaliana]]
[[Category: Arvai, A S]]
[[Category: Large Structures]]
[[Category: Getzoff, E D]]
[[Category: Arvai AS]]
[[Category: Hitomi, K]]
[[Category: Getzoff ED]]
[[Category: Aba]]
[[Category: Hitomi K]]
[[Category: Aba receptor]]
[[Category: Aba sensor]]
[[Category: Abscisic acid]]
[[Category: Alpha/beta helix-grip fold]]
[[Category: Drought tolerance]]
[[Category: Hormone receptor]]
[[Category: Phytohormone]]
[[Category: Plant development]]
[[Category: Plant hormone receptor]]
[[Category: Pyl]]
[[Category: Pyr1]]
[[Category: Pyrabactin]]
[[Category: Pyrabactin resistance 1]]
[[Category: Seed dormancy]]
[[Category: Signaling protein]]
[[Category: Start protein]]

Latest revision as of 08:08, 6 September 2023

Crystal structure of dimeric abscisic acid (ABA) receptor pyrabactin resistance 1 (PYR1) with ABA-bound closed-lid and ABA-free open-lid subunits

3k3k, resolution 1.70Å

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