3k6z: Difference between revisions

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<StructureSection load='3k6z' size='340' side='right'caption='[[3k6z]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
<StructureSection load='3k6z' size='340' side='right'caption='[[3k6z]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3k6z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K6Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K6Z FirstGlance]. <br>
<table><tr><td colspan='2'>[[3k6z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K6Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K6Z FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3k6y|3k6y]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MT3772, Rv3671c ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k6z OCA], [https://pdbe.org/3k6z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k6z RCSB], [https://www.ebi.ac.uk/pdbsum/3k6z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k6z ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k6z OCA], [https://pdbe.org/3k6z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k6z RCSB], [https://www.ebi.ac.uk/pdbsum/3k6z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k6z ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/Y3671_MYCTU Y3671_MYCTU]] Required for M.tuberculosis resistance to oxidative stress in addition to its role in resistance to acid, which is essential for virulence. It protects M.tuberculosis against phagolysosomal concentrations of acid and maintains its intrabacterial pH when phagocytosed by IFN-gamma-activated macrophages.<ref>PMID:18641659</ref> <ref>PMID:20947023</ref>
[https://www.uniprot.org/uniprot/Y3671_MYCTU Y3671_MYCTU] Required for M.tuberculosis resistance to oxidative stress in addition to its role in resistance to acid, which is essential for virulence. It protects M.tuberculosis against phagolysosomal concentrations of acid and maintains its intrabacterial pH when phagocytosed by IFN-gamma-activated macrophages.<ref>PMID:18641659</ref> <ref>PMID:20947023</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Biswas, T]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Ehrt, S]]
[[Category: Biswas T]]
[[Category: Small, J]]
[[Category: Ehrt S]]
[[Category: Tsodikov, O V]]
[[Category: Small J]]
[[Category: Vandal, O]]
[[Category: Tsodikov OV]]
[[Category: Bent helix]]
[[Category: Vandal O]]
[[Category: Disulfide]]
[[Category: Hydrolase]]
[[Category: Oxidative stress]]
[[Category: Protease]]
[[Category: Serine protease]]
Retrieved from "https://proteopedia.org/3k6z"