3l07: Difference between revisions

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==Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase, putative bifunctional protein folD from Francisella tularensis.==
==Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase, putative bifunctional protein folD from Francisella tularensis.==
<StructureSection load='3l07' size='340' side='right' caption='[[3l07]], [[Resolution|resolution]] 1.88&Aring;' scene=''>
<StructureSection load='3l07' size='340' side='right'caption='[[3l07]], [[Resolution|resolution]] 1.88&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3l07]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Fratt Fratt]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L07 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3L07 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3l07]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Francisella_tularensis_subsp._tularensis_SCHU_S4 Francisella tularensis subsp. tularensis SCHU S4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L07 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L07 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.88&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">folD, FTW_1287 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=177416 FRATT])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l07 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l07 OCA], [http://pdbe.org/3l07 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3l07 RCSB], [http://www.ebi.ac.uk/pdbsum/3l07 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3l07 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l07 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l07 OCA], [https://pdbe.org/3l07 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l07 RCSB], [https://www.ebi.ac.uk/pdbsum/3l07 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l07 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/FOLD_FRATW FOLD_FRATW]] Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate (By similarity).  
[https://www.uniprot.org/uniprot/FOLD_FRATT FOLD_FRATT] Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.[HAMAP-Rule:MF_01576]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l0/3l07_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l0/3l07_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Fratt]]
[[Category: Francisella tularensis subsp. tularensis SCHU S4]]
[[Category: Anderson, W F]]
[[Category: Large Structures]]
[[Category: Structural genomic]]
[[Category: Anderson WF]]
[[Category: Hasseman, J]]
[[Category: Hasseman J]]
[[Category: Joachimiak, A]]
[[Category: Joachimiak A]]
[[Category: Maltseva, N]]
[[Category: Maltseva N]]
[[Category: Mulligan, R]]
[[Category: Mulligan R]]
[[Category: Osipiuk, J]]
[[Category: Osipiuk J]]
[[Category: Amino-acid biosynthesis]]
[[Category: Bifunctional protein]]
[[Category: Csgid]]
[[Category: Histidine biosynthesis]]
[[Category: Hydrolase]]
[[Category: Idp01849]]
[[Category: Methenyltetrahydrofolate cyclohydrolase]]
[[Category: Methionine biosynthesis]]
[[Category: Methylenetetrahydrofolate dehydrogenase]]
[[Category: Multifunctional enzyme]]
[[Category: Nadp]]
[[Category: One-carbon metabolism]]
[[Category: Oxidoreductase]]
[[Category: Purine biosynthesis]]
Retrieved from "https://proteopedia.org/3l07"