3l38: Difference between revisions

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==Bace1 in complex with the aminopyridine Compound 44==
==Bace1 in complex with the aminopyridine Compound 44==
<StructureSection load='3l38' size='340' side='right' caption='[[3l38]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='3l38' size='340' side='right'caption='[[3l38]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3l38]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L38 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3L38 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3l38]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L38 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L38 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=879:6-({2-(2-CHLOROPHENYL)-5-[4-(PYRIMIDIN-5-YLOXY)PHENYL]-1H-PYRROL-1-YL}METHYL)PYRIDIN-2-AMINE'>879</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3l3a|3l3a]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=879:6-({2-(2-CHLOROPHENYL)-5-[4-(PYRIMIDIN-5-YLOXY)PHENYL]-1H-PYRROL-1-YL}METHYL)PYRIDIN-2-AMINE'>879</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BACE1, BACE, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l38 OCA], [https://pdbe.org/3l38 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l38 RCSB], [https://www.ebi.ac.uk/pdbsum/3l38 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l38 ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l38 OCA], [http://pdbe.org/3l38 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3l38 RCSB], [http://www.ebi.ac.uk/pdbsum/3l38 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3l38 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[Beta secretase|Beta secretase]]
*[[Beta secretase 3D structures|Beta secretase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Memapsin 2]]
[[Category: Large Structures]]
[[Category: Chopra, R]]
[[Category: Chopra R]]
[[Category: Olland, A M]]
[[Category: Olland AM]]
[[Category: Aminopyridine]]
[[Category: Aspartyl protease]]
[[Category: Bace-1]]
[[Category: Beta-secretase]]
[[Category: Disulfide bond]]
[[Category: Hydrolase]]
[[Category: Inhibitor]]
[[Category: Protease]]
[[Category: Transmembrane]]
[[Category: Zymogen]]
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