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==Crystal structure of sterol 14-alpha demethylase (CYP51) from Leishmania infantum in complex with fluconazole==
==Crystal structure of sterol 14-alpha demethylase (CYP51) from Leishmania infantum in complex with fluconazole==
<StructureSection load='3l4d' size='340' side='right' caption='[[3l4d]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
<StructureSection load='3l4d' size='340' side='right'caption='[[3l4d]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3l4d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Leiin Leiin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L4D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3L4D FirstGlance]. <br>
<table><tr><td colspan='2'>[[3l4d]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_infantum Leishmania infantum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L4D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L4D FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=N8E:3,6,9,12,15-PENTAOXATRICOSAN-1-OL'>N8E</scene>, <scene name='pdbligand=TPF:2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL'>TPF</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CYP51, LinJ11.1100 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5671 LEIIN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=N8E:3,6,9,12,15-PENTAOXATRICOSAN-1-OL'>N8E</scene>, <scene name='pdbligand=TPF:2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL'>TPF</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sterol_14-demethylase Sterol 14-demethylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.70 1.14.13.70] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l4d OCA], [https://pdbe.org/3l4d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l4d RCSB], [https://www.ebi.ac.uk/pdbsum/3l4d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l4d ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l4d OCA], [http://pdbe.org/3l4d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3l4d RCSB], [http://www.ebi.ac.uk/pdbsum/3l4d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3l4d ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A2TEF2_LEIIN A2TEF2_LEIIN]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</div>
</div>
<div class="pdbe-citations 3l4d" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3l4d" style="background-color:#fffaf0;"></div>
==See Also==
*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Leiin]]
[[Category: Large Structures]]
[[Category: Sterol 14-demethylase]]
[[Category: Leishmania infantum]]
[[Category: Hargrove, T Y]]
[[Category: Hargrove TY]]
[[Category: Lepesheva, G I]]
[[Category: Lepesheva GI]]
[[Category: Waterman, M R]]
[[Category: Waterman MR]]
[[Category: Wawrzak, Z]]
[[Category: Wawrzak Z]]
[[Category: Cyp51]]
[[Category: Endoplasmic reticulum]]
[[Category: Heme]]
[[Category: Iron]]
[[Category: Lipid]]
[[Category: Membrane]]
[[Category: Monooxygenase]]
[[Category: Obtusifoliol]]
[[Category: Oxidoreductase]]
[[Category: P450]]
[[Category: Sterol 14-alpha demethylase]]
[[Category: Sterol biosynthesis]]
[[Category: Transmembrane protein]]
Retrieved from "https://proteopedia.org/3l4d"