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==Crystal Structure Analysis of WbgU: a UDP-GalNAc 4-epimerase==
==Crystal Structure Analysis of WbgU: a UDP-GalNAc 4-epimerase==
<StructureSection load='3lu1' size='340' side='right' caption='[[3lu1]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='3lu1' size='340' side='right'caption='[[3lu1]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3lu1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"aeromonas_shigelloides"_(bader_1954)_ewing_et_al._1961 "aeromonas shigelloides" (bader 1954) ewing et al. 1961]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LU1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LU1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3lu1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Plesiomonas_shigelloides Plesiomonas shigelloides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LU1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LU1 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UD2:URIDINE-DIPHOSPHATE-N-ACETYLGALACTOSAMINE'>UD2</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">wbgU ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=703 "Aeromonas shigelloides" (Bader 1954) Ewing et al. 1961])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UD2:URIDINE-DIPHOSPHATE-N-ACETYLGALACTOSAMINE'>UD2</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Isomerase Isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.3.7 5.1.3.7] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lu1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lu1 OCA], [https://pdbe.org/3lu1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lu1 RCSB], [https://www.ebi.ac.uk/pdbsum/3lu1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lu1 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lu1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lu1 OCA], [http://pdbe.org/3lu1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3lu1 RCSB], [http://www.ebi.ac.uk/pdbsum/3lu1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3lu1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GNE_PLESH GNE_PLESH] Catalyzes the epimerization of UDP-N-acetylglucosamine (UDP-GlcNAc) to UDP-N-acetylgalactosamine (UDP-GalNAc). Has very low epimerase activity with UDP-Glc and UDP-Gal. Plays a role in the biosynthesis of 2-acetamino-2-deoxy-L-altruronic acid, a building block of the O-antigen in bacterial lipopolysaccharide (LPS).<ref>PMID:12484781</ref> <ref>PMID:21810411</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lu/3lu1_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lu/3lu1_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Isomerase]]
[[Category: Large Structures]]
[[Category: Bhatt, V S]]
[[Category: Plesiomonas shigelloides]]
[[Category: Guo, C Y]]
[[Category: Bhatt VS]]
[[Category: Liu, Z J]]
[[Category: Guo CY]]
[[Category: Wang, P G]]
[[Category: Liu ZJ]]
[[Category: Yi, W]]
[[Category: Wang PG]]
[[Category: Zhao, G]]
[[Category: Yi W]]
[[Category: Epimerase]]
[[Category: Zhao G]]
[[Category: Glycan]]
[[Category: Lipopolysaccharide]]
[[Category: Nadh]]
[[Category: Rossmann fold]]
[[Category: Udp-glcnac]]
Retrieved from "https://proteopedia.org/3lu1"