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==Crystal Structure of INPP5B in complex with phosphatidylinositol 4-phosphate==
==Crystal Structure of INPP5B in complex with phosphatidylinositol 4-phosphate==
<StructureSection load='3mtc' size='340' side='right' caption='[[3mtc]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='3mtc' size='340' side='right'caption='[[3mtc]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3mtc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MTC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MTC FirstGlance]. <br>
<table><tr><td colspan='2'>[[3mtc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MTC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MTC FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PIF:(2R)-3-{[(S)-HYDROXY{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-TETRAHYDROXY-4-(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL]OXY}PROPANE-1,2-DIYL+DIOCTANOATE'>PIF</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3n9v|3n9v]], [[3nr8|3nr8]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PIF:(2R)-3-{[(S)-HYDROXY{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-TETRAHYDROXY-4-(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL]OXY}PROPANE-1,2-DIYL+DIOCTANOATE'>PIF</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">INPP5B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mtc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mtc OCA], [https://pdbe.org/3mtc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mtc RCSB], [https://www.ebi.ac.uk/pdbsum/3mtc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mtc ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoinositide_5-phosphatase Phosphoinositide 5-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.36 3.1.3.36] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mtc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mtc OCA], [http://pdbe.org/3mtc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mtc RCSB], [http://www.ebi.ac.uk/pdbsum/3mtc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mtc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/I5P2_HUMAN I5P2_HUMAN]] Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events.<ref>PMID:7721860</ref>
[https://www.uniprot.org/uniprot/I5P2_HUMAN I5P2_HUMAN] Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events.<ref>PMID:7721860</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[Phosphoinositide phosphatase|Phosphoinositide phosphatase]]
*[[Phosphoinositide phosphatase|Phosphoinositide phosphatase]]
*[[3D structures of inositol polyphosphate 5-phosphatase OCRL|3D structures of inositol polyphosphate 5-phosphatase OCRL]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Phosphoinositide 5-phosphatase]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith CH]]
[[Category: Berg, S van der]]
[[Category: Berglund H]]
[[Category: Berglund, H]]
[[Category: Bountra C]]
[[Category: Bountra, C]]
[[Category: Collins R]]
[[Category: Collins, R]]
[[Category: Edwards AM]]
[[Category: Edwards, A M]]
[[Category: Flodin S]]
[[Category: Flodin, S]]
[[Category: Flores A]]
[[Category: Flores, A]]
[[Category: Graslund S]]
[[Category: Graslund, S]]
[[Category: Hammarstrom M]]
[[Category: Hammarstrom, M]]
[[Category: Johansson I]]
[[Category: Johansson, I]]
[[Category: Karlberg T]]
[[Category: Karlberg, T]]
[[Category: Kol S]]
[[Category: Kol, S]]
[[Category: Kotenyova T]]
[[Category: Kotenyova, T]]
[[Category: Moche M]]
[[Category: Moche, M]]
[[Category: Nordlund P]]
[[Category: Nordlund, P]]
[[Category: Nyman T]]
[[Category: Nyman, T]]
[[Category: Persson C]]
[[Category: Persson, C]]
[[Category: Schuler H]]
[[Category: Structural genomic]]
[[Category: Schutz P]]
[[Category: Schuler, H]]
[[Category: Siponen MI]]
[[Category: Schutz, P]]
[[Category: Thorsell AG]]
[[Category: Siponen, M I]]
[[Category: Tresaugues L]]
[[Category: Thorsell, A G]]
[[Category: Wahlberg E]]
[[Category: Tresaugues, L]]
[[Category: Weigelt J]]
[[Category: Wahlberg, E]]
[[Category: Welin M]]
[[Category: Weigelt, J]]
[[Category: Wisniewska M]]
[[Category: Welin, M]]
[[Category: Van der Berg S]]
[[Category: Wisniewska, M]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Inositol signalling]]
[[Category: Inpp5ba]]
[[Category: Magnesium]]
[[Category: Phosphatase]]
[[Category: Sgc]]
[[Category: Sgc stockholm]]
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