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<StructureSection load='3n8n' size='340' side='right'caption='[[3n8n]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='3n8n' size='340' side='right'caption='[[3n8n]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3n8n]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N8N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N8N FirstGlance]. <br>
<table><tr><td colspan='2'>[[3n8n]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N8N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N8N FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=N88:(1R,4R,5R)-3-(TERT-BUTYLCARBAMOYL)-1,4,5-TRIHYDROXYCYCLOHEX-2-ENE-1-CARBOXYLIC+ACID'>N88</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3n76|3n76]], [[3n7a|3n7a]], [[3n86|3n86]], [[3n87|3n87]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=N88:(1R,4R,5R)-3-(TERT-BUTYLCARBAMOYL)-1,4,5-TRIHYDROXYCYCLOHEX-2-ENE-1-CARBOXYLIC+ACID'>N88</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">aroD, aroQ, MT2612, MTCY159.19, Rv2537c ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n8n OCA], [https://pdbe.org/3n8n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n8n RCSB], [https://www.ebi.ac.uk/pdbsum/3n8n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n8n ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n8n OCA], [https://pdbe.org/3n8n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n8n RCSB], [https://www.ebi.ac.uk/pdbsum/3n8n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n8n ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/AROQ_MYCTU AROQ_MYCTU]] Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169]  
[https://www.uniprot.org/uniprot/AROQ_MYCTU AROQ_MYCTU] Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: 3-dehydroquinate dehydratase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Abell, C]]
[[Category: Blundell, T L]]
[[Category: Bromfield, K M]]
[[Category: Ciulli, A]]
[[Category: Dias, M V.B]]
[[Category: Howard, N I]]
[[Category: Palaninathan, S K]]
[[Category: Payne, R]]
[[Category: Sacchettini, J C]]
[[Category: Snee, W C]]
[[Category: Arod]]
[[Category: Dehydroquinate dehydratase]]
[[Category: Drug discovery]]
[[Category: Lyase]]
[[Category: Lyase-lyase inhibitor complex]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Shikimate pathway]]
[[Category: Abell C]]
[[Category: Blundell TL]]
[[Category: Bromfield KM]]
[[Category: Ciulli A]]
[[Category: Dias MVB]]
[[Category: Howard NI]]
[[Category: Palaninathan SK]]
[[Category: Payne R]]
[[Category: Sacchettini JC]]
[[Category: Snee WC]]
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