3na1: Difference between revisions

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<StructureSection load='3na1' size='340' side='right'caption='[[3na1]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
<StructureSection load='3na1' size='340' side='right'caption='[[3na1]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3na1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NA1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NA1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3na1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NA1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NA1 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=HCD:(3ALPHA,8ALPHA)-CHOLEST-5-ENE-3,20-DIOL'>HCD</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3n9y|3n9y]], [[3n9z|3n9z]], [[3na0|3na0]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=HCD:(3ALPHA,8ALPHA)-CHOLEST-5-ENE-3,20-DIOL'>HCD</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CYP11A, CYP11A1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), adrenodoxin, ADX, FDX1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cholesterol_monooxygenase_(side-chain-cleaving) Cholesterol monooxygenase (side-chain-cleaving)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.15.6 1.14.15.6] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3na1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3na1 OCA], [https://pdbe.org/3na1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3na1 RCSB], [https://www.ebi.ac.uk/pdbsum/3na1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3na1 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3na1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3na1 OCA], [https://pdbe.org/3na1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3na1 RCSB], [https://www.ebi.ac.uk/pdbsum/3na1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3na1 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[https://www.uniprot.org/uniprot/CP11A_HUMAN CP11A_HUMAN]] Inherited isolated adrenal insufficiency due to CYP11A1 deficiency;46,XY disorder of sex development - adrenal insufficiency due to CYP11A1 deficiency. The disease is caused by mutations affecting the gene represented in this entry.  
[https://www.uniprot.org/uniprot/CP11A_HUMAN CP11A_HUMAN] Inherited isolated adrenal insufficiency due to CYP11A1 deficiency;46,XY disorder of sex development - adrenal insufficiency due to CYP11A1 deficiency. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/CP11A_HUMAN CP11A_HUMAN]] Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.<ref>PMID:21636783</ref> [[https://www.uniprot.org/uniprot/ADX_HUMAN ADX_HUMAN]] Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage.<ref>PMID:20547883</ref> <ref>PMID:21636783</ref> 
[https://www.uniprot.org/uniprot/CP11A_HUMAN CP11A_HUMAN] Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.<ref>PMID:21636783</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith CH]]
[[Category: Botchkarev, A]]
[[Category: Botchkarev A]]
[[Category: Bountra, C]]
[[Category: Bountra C]]
[[Category: Edwards, A M]]
[[Category: Edwards AM]]
[[Category: MacKenzie, F]]
[[Category: MacKenzie F]]
[[Category: Park, H]]
[[Category: Park H]]
[[Category: Structural genomic]]
[[Category: Strushkevich NV]]
[[Category: Strushkevich, N V]]
[[Category: Tempel W]]
[[Category: Tempel, W]]
[[Category: Weigelt JU]]
[[Category: Weigelt, J U]]
[[Category: 20-hydroxycholesterol]]
[[Category: Cholesterol side chain cleavage]]
[[Category: Cytochrome p450]]
[[Category: Electron transport]]
[[Category: Oxidoreductase]]
[[Category: Sgc]]
Retrieved from "https://proteopedia.org/3na1"