3nds: Difference between revisions

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<StructureSection load='3nds' size='340' side='right'caption='[[3nds]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
<StructureSection load='3nds' size='340' side='right'caption='[[3nds]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3nds]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NDS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3NDS FirstGlance]. <br>
<table><tr><td colspan='2'>[[3nds]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_pallida Naja pallida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NDS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NDS FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1iq9|1iq9]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3nds FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nds OCA], [http://pdbe.org/3nds PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3nds RCSB], [http://www.ebi.ac.uk/pdbsum/3nds PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3nds ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nds FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nds OCA], [https://pdbe.org/3nds PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nds RCSB], [https://www.ebi.ac.uk/pdbsum/3nds PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nds ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/NXS1_NAJPA NXS1_NAJPA]] Binds with high affinity to muscular nicotinic acetylcholine receptors (nAChRs), and with low affinity to neuronal alpha-7 nAChRs. Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site.<ref>PMID:9305882</ref>
[https://www.uniprot.org/uniprot/3S11_NAJPA 3S11_NAJPA] Binds with high affinity to muscular nicotinic acetylcholine receptors (nAChRs) (tested on Torpedo marmorata AChR, Kd=0.07 nM) and with low affinity to neuronal alpha-7/CHRNA7 nAChRs (tested on chimeric receptor, Kd=3 uM) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission (PubMed:9305882). Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site.<ref>PMID:9305882</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Drevet, P]]
[[Category: Naja pallida]]
[[Category: Gallopin, M]]
[[Category: Drevet P]]
[[Category: Gregory, G]]
[[Category: Gallopin M]]
[[Category: Stura, E A]]
[[Category: Gregory G]]
[[Category: Vandame, M]]
[[Category: Stura EA]]
[[Category: Disulfide pairing]]
[[Category: Vandame M]]
[[Category: Folding intermediate]]
[[Category: Snake toxin]]
[[Category: Three finger toxin fold]]
[[Category: Toxin]]
[[Category: Venom]]
Retrieved from "https://proteopedia.org/3nds"