3nfl: Difference between revisions

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<StructureSection load='3nfl' size='340' side='right'caption='[[3nfl]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
<StructureSection load='3nfl' size='340' side='right'caption='[[3nfl]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3nfl]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NFL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NFL FirstGlance]. <br>
<table><tr><td colspan='2'>[[3nfl]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NFL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NFL FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2vph|2vph]], [[2cs5|2cs5]], [[3nfk|3nfk]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.91&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTPN4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nfl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nfl OCA], [https://pdbe.org/3nfl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nfl RCSB], [https://www.ebi.ac.uk/pdbsum/3nfl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nfl ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nfl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nfl OCA], [https://pdbe.org/3nfl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nfl RCSB], [https://www.ebi.ac.uk/pdbsum/3nfl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nfl ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[[https://www.uniprot.org/uniprot/NMDE1_HUMAN NMDE1_HUMAN]] Landau-Kleffner syndrome;Early-onset epileptic encephalopathy and intellectual disability due to GRIN2A mutation;Continuous spikes and waves during sleep;Rolandic epilepsy;Rolandic epilepsy - speech dyspraxia. The disease is caused by mutations affecting the gene represented in this entry.  A chromosomal aberration involving GRIN2A has been found in a family with epilepsy and neurodevelopmental defects. Translocation t(16;17)(p13.2;q11.2).  GRIN2A somatic mutations have been frequently found in cutaneous malignant melanoma, suggesting that the glutamate signaling pathway may play a role in the pathogenesis of melanoma.<ref>PMID:21499247</ref> <ref>PMID:24455489</ref> 
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/PTN4_HUMAN PTN4_HUMAN]] May act at junctions between the membrane and the cytoskeleton. [[https://www.uniprot.org/uniprot/NMDE1_HUMAN NMDE1_HUMAN]] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits.  
[https://www.uniprot.org/uniprot/PTN4_HUMAN PTN4_HUMAN] May act at junctions between the membrane and the cytoskeleton.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Babault, N]]
[[Category: Babault N]]
[[Category: Buc, H]]
[[Category: Buc H]]
[[Category: Cockburn, J]]
[[Category: Cockburn J]]
[[Category: Cordier, F]]
[[Category: Cordier F]]
[[Category: Delepierre, M]]
[[Category: Delepierre M]]
[[Category: Haouz, A]]
[[Category: Haouz A]]
[[Category: Lafage, M]]
[[Category: Lafage M]]
[[Category: Lafon, M]]
[[Category: Lafon M]]
[[Category: Rey, F A]]
[[Category: Rey FA]]
[[Category: Wolff, N]]
[[Category: Wolff N]]
[[Category: Pdz-pdz-binding site complex]]
[[Category: Protein binding]]
Retrieved from "https://proteopedia.org/3nfl"