3op5: Difference between revisions

<StructureSection load='3op5' size='340' side='right'caption='[[3op5]], [[Resolution|resolution]] 2.40&Aring;' scene=''>

<table><tr><td colspan='2'>[[3op5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OP5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OP5 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=REB:[4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETONITRILE'>REB</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3op5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3op5 OCA], [https://pdbe.org/3op5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3op5 RCSB], [https://www.ebi.ac.uk/pdbsum/3op5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3op5 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN] Pontocerebellar hypoplasia type 1. The disease is caused by mutations affecting the gene represented in this entry.

[https://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN] Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity.<ref>PMID:10951572</ref> <ref>PMID:14645249</ref> <ref>PMID:15105425</ref> <ref>PMID:16495336</ref> <ref>PMID:18617507</ref> <ref>PMID:19103756</ref>  

*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Allerston CK]]

[[Category: Arrowsmith CH]]

[[Category: Berridge G]]

[[Category: Bountra C]]

[[Category: Brenner B]]

[[Category: Chalk R]]

[[Category: Das S]]

[[Category: Edwards AM]]

[[Category: Elkins JM]]

[[Category: Eswaran J]]

[[Category: Fedorov O]]

[[Category: Filippakopoulos P]]

[[Category: Gileadi O]]

[[Category: Keates T]]

[[Category: King O]]

[[Category: Knapp S]]

[[Category: Krojer T]]

[[Category: Rellos P]]

[[Category: Savitsky P]]

[[Category: Uttarkar S]]

[[Category: Weigelt J]]

[[Category: Von Delft F]]