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<StructureSection load='3pcs' size='340' side='right'caption='[[3pcs]], [[Resolution|resolution]] 2.86&Aring;' scene=''>
<StructureSection load='3pcs' size='340' side='right'caption='[[3pcs]], [[Resolution|resolution]] 2.86&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3pcs]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Eco57 Eco57] and [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PCS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PCS FirstGlance]. <br>
<table><tr><td colspan='2'>[[3pcs]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PCS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PCS FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3pcr|3pcr]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.86&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ECs4590, espG, Z5142 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83334 ECO57]), PAK2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pcs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pcs OCA], [https://pdbe.org/3pcs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pcs RCSB], [https://www.ebi.ac.uk/pdbsum/3pcs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pcs ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pcs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pcs OCA], [https://pdbe.org/3pcs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pcs RCSB], [https://www.ebi.ac.uk/pdbsum/3pcs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pcs ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/PAK2_HUMAN PAK2_HUMAN]] Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Phosphorylates JUN and plays an important role in EGF-induced cell proliferation. Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP. Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis. On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway. Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation.<ref>PMID:12853446</ref> <ref>PMID:15234964</ref> <ref>PMID:16617111</ref> <ref>PMID:19923322</ref> <ref>PMID:21177766</ref> <ref>PMID:21317288</ref> <ref>PMID:21724829</ref> <ref>PMID:9171063</ref> 
[https://www.uniprot.org/uniprot/Q7DB50_ECO57 Q7DB50_ECO57]  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Eco57]]
[[Category: Escherichia coli O157:H7]]
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Alto NM]]
[[Category: Alto, N M]]
[[Category: Selyunin AS]]
[[Category: Selyunin, A S]]
[[Category: Tomchick DR]]
[[Category: Tomchick, D R]]
[[Category: Autoinhibitory ialpha3 helix]]
[[Category: Bacterial effector]]
[[Category: Kinase]]
[[Category: Protein transport-transferase complex]]
Retrieved from "https://proteopedia.org/3pcs"