3pry: Difference between revisions
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<StructureSection load='3pry' size='340' side='right'caption='[[3pry]], [[Resolution|resolution]] 2.28Å' scene=''> | <StructureSection load='3pry' size='340' side='right'caption='[[3pry]], [[Resolution|resolution]] 2.28Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3pry]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3pry]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PRY FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.28Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pry OCA], [https://pdbe.org/3pry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pry RCSB], [https://www.ebi.ac.uk/pdbsum/3pry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pry ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pry OCA], [https://pdbe.org/3pry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pry RCSB], [https://www.ebi.ac.uk/pdbsum/3pry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pry ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/HS90B_HUMAN HS90B_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:16478993</ref> <ref>PMID:19696785</ref> | |||
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith CH]] | ||
[[Category: Ayinampudi | [[Category: Ayinampudi V]] | ||
[[Category: Berridge | [[Category: Berridge G]] | ||
[[Category: Bountra | [[Category: Bountra C]] | ||
[[Category: Bullock | [[Category: Bullock A]] | ||
[[Category: Chaikuad | [[Category: Chaikuad A]] | ||
[[Category: Che | [[Category: Che KH]] | ||
[[Category: Cooper | [[Category: Cooper CDO]] | ||
[[Category: Edwards A]] | |||
[[Category: Edwards | [[Category: Fedorov O]] | ||
[[Category: Fedorov | [[Category: Keates T]] | ||
[[Category: Keates | [[Category: Krojer T]] | ||
[[Category: Krojer | [[Category: Muniz JRC]] | ||
[[Category: Muniz | [[Category: Phillips C]] | ||
[[Category: Phillips | [[Category: Pilka E]] | ||
[[Category: Pilka | [[Category: Sharpe TD]] | ||
[[Category: Thangaratnarajah C]] | |||
[[Category: Sharpe | [[Category: Vollmar M]] | ||
[[Category: Thangaratnarajah | [[Category: Weigelt J]] | ||
[[Category: Vollmar | [[Category: Yue WW]] | ||
[[Category: Weigelt | [[Category: Zimmermann T]] | ||
[[Category: Yue | [[Category: Von Delft F]] | ||
[[Category: Zimmermann | |||
[[Category: | |||
Latest revision as of 10:00, 6 September 2023
Crystal structure of the middle domain of human HSP90-beta refined at 2.3 A resolution
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