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<StructureSection load='5j1v' size='340' side='right'caption='[[5j1v]], [[Resolution|resolution]] 2.52&Aring;' scene=''>
<StructureSection load='5j1v' size='340' side='right'caption='[[5j1v]], [[Resolution|resolution]] 2.52&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5j1v]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J1V OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5J1V FirstGlance]. <br>
<table><tr><td colspan='2'>[[5j1v]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J1V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J1V FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6FD:PYRIDO[3,4-G]QUINAZOLINE-2,10-DIAMINE'>6FD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.52&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CLK1, CLK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6FD:PYRIDO[3,4-G]QUINAZOLINE-2,10-DIAMINE'>6FD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j1v OCA], [https://pdbe.org/5j1v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j1v RCSB], [https://www.ebi.ac.uk/pdbsum/5j1v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j1v ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5j1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j1v OCA], [http://pdbe.org/5j1v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j1v RCSB], [http://www.ebi.ac.uk/pdbsum/5j1v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j1v ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CLK1_HUMAN CLK1_HUMAN]] Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.<ref>PMID:10480872</ref> <ref>PMID:19168442</ref>
[https://www.uniprot.org/uniprot/CLK1_HUMAN CLK1_HUMAN] Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.<ref>PMID:10480872</ref> <ref>PMID:19168442</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Dual-specificity kinase]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Anizon, F]]
[[Category: Anizon F]]
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith CH]]
[[Category: Boibessot, T]]
[[Category: Boibessot T]]
[[Category: Bountra, C]]
[[Category: Bountra C]]
[[Category: Chaikuad, A]]
[[Category: Chaikuad A]]
[[Category: Delft, F von]]
[[Category: Edwards AM]]
[[Category: Edwards, A M]]
[[Category: Esvan YJ]]
[[Category: Esvan, Y J]]
[[Category: Giraud F]]
[[Category: Giraud, F]]
[[Category: Knapp S]]
[[Category: Knapp, S]]
[[Category: Loaec N]]
[[Category: Loaec, N]]
[[Category: Meijer L]]
[[Category: Meijer, L]]
[[Category: Moreau P]]
[[Category: Moreau, P]]
[[Category: Nauton L]]
[[Category: Nauton, L]]
[[Category: Thery V]]
[[Category: Structural genomic]]
[[Category: Zeinyeh W]]
[[Category: Thery, V]]
[[Category: Von Delft F]]
[[Category: Zeinyeh, W]]
[[Category: Inhibitor]]
[[Category: Nucleus]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Sgc]]
[[Category: Transferase]]
[[Category: Tyrosine-protein kinase]]
Retrieved from "https://proteopedia.org/5j1v"