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==Crystal Structure of Human THYN1 protein in complex with 5-methylcytosine containing DNA==
==Crystal Structure of Human THYN1 protein in complex with 5-methylcytosine containing DNA==
<StructureSection load='5j3e' size='340' side='right' caption='[[5j3e]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='5j3e' size='340' side='right'caption='[[5j3e]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5j3e]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J3E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J3E FirstGlance]. <br>
<table><tr><td colspan='2'>[[5j3e]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J3E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J3E FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">THYN1, THY28, HSPC144, MDS012, My0054 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j3e OCA], [https://pdbe.org/5j3e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j3e RCSB], [https://www.ebi.ac.uk/pdbsum/5j3e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j3e ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j3e OCA], [http://pdbe.org/5j3e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j3e RCSB], [http://www.ebi.ac.uk/pdbsum/5j3e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j3e ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/THYN1_HUMAN THYN1_HUMAN]] Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.  
[https://www.uniprot.org/uniprot/THYN1_HUMAN THYN1_HUMAN] Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H]]
[[Category: Large Structures]]
[[Category: Bountra, C]]
[[Category: Arrowsmith CH]]
[[Category: Edwards, A M]]
[[Category: Bountra C]]
[[Category: Halabelian, L]]
[[Category: Edwards AM]]
[[Category: Li, Y]]
[[Category: Halabelian L]]
[[Category: Structural genomic]]
[[Category: Li Y]]
[[Category: Tempel, W]]
[[Category: Tempel W]]
[[Category: 5-methylcytosine containing dna]]
[[Category: Modified dna]]
[[Category: Nuclear protein-dna complex]]
[[Category: Protein-dna complex]]
[[Category: Sgc]]
Retrieved from "https://proteopedia.org/5j3e"