5j7e: Difference between revisions

Latest revision as of 10:52, 6 September 2023

hEAG PAS domain

Structural highlights

5j7e is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.9Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

KCNH1_HUMAN The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.

Function

KCNH1_HUMAN Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed:22732247). Channel properties may be modulated by subunit assembly, but not by cyclic nucleotides (By similarity). Mediates IK(NI) current in myoblasts (PubMed:9738473). Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (PubMed:23881642).[UniProtKB:Q60603]^[1] ^[2] ^[3]

References

↑ Marques-Carvalho MJ, Sahoo N, Muskett FW, Vieira-Pires RS, Gabant G, Cadene M, Schonherr R, Morais-Cabral JH. Structural, Biochemical, and Functional Characterization of the Cyclic Nucleotide Binding Homology Domain from the Mouse EAG1 Potassium Channel. J Mol Biol. 2012 Jun 23. PMID:22732247 doi:10.1016/j.jmb.2012.06.025
↑ Zhang YY, Yue J, Che H, Sun HY, Tse HF, Li GR. BKCa and hEag1 channels regulate cell proliferation and differentiation in human bone marrow-derived mesenchymal stem cells. J Cell Physiol. 2014 Feb;229(2):202-12. doi: 10.1002/jcp.24435. PMID:23881642 doi:https://dx.doi.org/10.1002/jcp.24435
↑ Occhiodoro T, Bernheim L, Liu JH, Bijlenga P, Sinnreich M, Bader CR, Fischer-Lougheed J. Cloning of a human ether-a-go-go potassium channel expressed in myoblasts at the onset of fusion. FEBS Lett. 1998 Aug 28;434(1-2):177-82. PMID:9738473

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OCA

[1] Marques-Carvalho MJ, Sahoo N, Muskett FW, Vieira-Pires RS, Gabant G, Cadene M, Schonherr R, Morais-Cabral JH. Structural, Biochemical, and Functional Characterization of the Cyclic Nucleotide Binding Homology Domain from the Mouse EAG1 Potassium Channel. J Mol Biol. 2012 Jun 23. PMID:22732247 doi:10.1016/j.jmb.2012.06.025

[2] Zhang YY, Yue J, Che H, Sun HY, Tse HF, Li GR. BKCa and hEag1 channels regulate cell proliferation and differentiation in human bone marrow-derived mesenchymal stem cells. J Cell Physiol. 2014 Feb;229(2):202-12. doi: 10.1002/jcp.24435. PMID:23881642 doi:https://dx.doi.org/10.1002/jcp.24435

[3] Occhiodoro T, Bernheim L, Liu JH, Bijlenga P, Sinnreich M, Bader CR, Fischer-Lougheed J. Cloning of a human ether-a-go-go potassium channel expressed in myoblasts at the onset of fusion. FEBS Lett. 1998 Aug 28;434(1-2):177-82. PMID:9738473

[1]

[2]

[3]

@@ Line 3: / Line 3: @@
 <StructureSection load='5j7e' size='340' side='right'caption='[[5j7e]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5j7e]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J7E OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5J7E FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5j7e]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J7E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J7E FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KCNH1, EAG, EAG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5j7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j7e OCA], [http://pdbe.org/5j7e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j7e RCSB], [http://www.ebi.ac.uk/pdbsum/5j7e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j7e ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j7e OCA], [https://pdbe.org/5j7e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j7e RCSB], [https://www.ebi.ac.uk/pdbsum/5j7e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j7e ProSAT]</span></td></tr>
 </table>
 == Disease ==
-[[http://www.uniprot.org/uniprot/KCNH1_HUMAN KCNH1_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
+[https://www.uniprot.org/uniprot/KCNH1_HUMAN KCNH1_HUMAN] The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
 == Function ==
-[[http://www.uniprot.org/uniprot/KCNH1_HUMAN KCNH1_HUMAN]] Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed:22732247). Channel properties may be modulated by subunit assembly, but not by cyclic nucleotides (By similarity). Mediates IK(NI) current in myoblasts (PubMed:9738473). Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (PubMed:23881642).[UniProtKB:Q60603]<ref>PMID:22732247</ref> <ref>PMID:23881642</ref> <ref>PMID:9738473</ref>
+[https://www.uniprot.org/uniprot/KCNH1_HUMAN KCNH1_HUMAN] Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed:22732247). Channel properties may be modulated by subunit assembly, but not by cyclic nucleotides (By similarity). Mediates IK(NI) current in myoblasts (PubMed:9738473). Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (PubMed:23881642).[UniProtKB:Q60603]<ref>PMID:22732247</ref> <ref>PMID:23881642</ref> <ref>PMID:9738473</ref>
 ==See Also==
@@ Line 18: / Line 18: @@
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Juan, S]]
+[[Category: Juan S]]
-[[Category: Xiaohong, Q]]
+[[Category: Xiaohong Q]]
-[[Category: Xue, T]]
+[[Category: Xue T]]
-[[Category: Ether-a-go-go channel]]
-[[Category: Kcnh channel]]
-[[Category: Pas domain]]
-[[Category: Transport protein]]

5j7e: Difference between revisions

Latest revision as of 10:52, 6 September 2023

hEAG PAS domain

Structural highlights

Disease

Function

See Also

References

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