4lu3

The crystal structure of the human carbonic anhydrase XIV

spinqualitylabelsall models 4lu3, resolution 2.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4lu3 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2Å Ligands: AZM, BMA, GOL, MAN, NAG, SO4, ZN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function CAH14_HUMAN Reversible hydration of carbon dioxide. Publication Abstract from PubMed Carbonic anhydrase isoform XIV (CA XIV) is the last member of the human (h) CA family discovered so far, being localized in brain, kidneys, colon, small intestine, urinary bladder, liver, and spinal cord. It has recently been described as a possible drug target for treatment of epilepsy, some retinopathies as well as some skin tumors. Human carbonic anhydrase (hCA) XIV is a membrane-associated protein consisting of an N-terminal extracellular domain, a putative transmembrane region, and a small cytoplasmic tail. In this article, we report the expression, purification, and the crystallographic structure of the entire extracellular domain of this enzyme. The analysis of the structure revealed the typical alpha-CA fold, in which a 10-stranded beta-sheet forms the core of the molecule, while the comparison with all the other membrane associated isoforms (hCAs IV, IX, and XII) allowed to identify the diverse oligomeric arrangement and the sequence and structural differences observed in the region 127-136 as the main factors to consider in the design of selective inhibitors for each one of the membrane associated alpha-CAs. (c) 2013 Wiley Periodicals, Inc. Biopolymers 101: 769-778, 2014. The structural comparison between membrane-associated human carbonic anhydrases provides insights into drug design of selective inhibitors.,Alterio V, Pan P, Parkkila S, Buonanno M, Supuran CT, Monti SM, De Simone G Biopolymers. 2014 Jul;101(7):769-78. doi: 10.1002/bip.22456. PMID:24374484 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Carbonic anhydrase 3D structures

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