5jy3: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
Line 3: Line 3:
<StructureSection load='5jy3' size='340' side='right'caption='[[5jy3]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='5jy3' size='340' side='right'caption='[[5jy3]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5jy3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JY3 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5JY3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5jy3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JY3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JY3 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6OX:2-[2-[2-[2,6-BIS(CHLORANYL)PHENYL]PROPAN-2-YL]-1-[2-FLUORANYL-4-[3-FLUORANYL-4-(HYDROXYMETHYL)-5-METHYLSULFONYL-PHENYL]PHENYL]IMIDAZOL-4-YL]PROPAN-2-OL'>6OX</scene>, <scene name='pdbligand=BU1:1,4-BUTANEDIOL'>BU1</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NR1H2, LXRB, NER, UNR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6OX:2-[2-[2-[2,6-BIS(CHLORANYL)PHENYL]PROPAN-2-YL]-1-[2-FLUORANYL-4-[3-FLUORANYL-4-(HYDROXYMETHYL)-5-METHYLSULFONYL-PHENYL]PHENYL]IMIDAZOL-4-YL]PROPAN-2-OL'>6OX</scene>, <scene name='pdbligand=BU1:1,4-BUTANEDIOL'>BU1</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5jy3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jy3 OCA], [http://pdbe.org/5jy3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jy3 RCSB], [http://www.ebi.ac.uk/pdbsum/5jy3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jy3 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jy3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jy3 OCA], [https://pdbe.org/5jy3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jy3 RCSB], [https://www.ebi.ac.uk/pdbsum/5jy3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jy3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/NR1H2_HUMAN NR1H2_HUMAN]] Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity).  
[https://www.uniprot.org/uniprot/NR1H2_HUMAN NR1H2_HUMAN] Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 26: Line 26:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Muckelbauer, J K]]
[[Category: Muckelbauer JK]]
[[Category: Lxr-b]]
[[Category: Lxrb]]
[[Category: Ner]]
[[Category: Ner-i]]
[[Category: Nhr]]
[[Category: Nr1h2]]
[[Category: Rip15]]
[[Category: Transcription]]
[[Category: Unr]]
Retrieved from "https://proteopedia.org/5jy3"