8fr7: Difference between revisions

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'''Unreleased structure'''


The entry 8fr7 is ON HOLD  until Paper Publication
==A hinge glycan regulates spike bending and impacts coronavirus infectivity==
 
<StructureSection load='8fr7' size='340' side='right'caption='[[8fr7]], [[Resolution|resolution]] 3.39&Aring;' scene=''>
Authors: Pintilie, G., Wilson, E., Chmielewski, D., Schmid, M.F., Jin, J., Chen, M., Singharoy, A., Chiu, W.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8fr7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_coronavirus_NL63 Human coronavirus NL63]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FR7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FR7 FirstGlance]. <br>
Description: A hinge glycan regulates spike bending and impacts coronavirus infectivity
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.39&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
[[Category: Chmielewski, D]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fr7 OCA], [https://pdbe.org/8fr7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fr7 RCSB], [https://www.ebi.ac.uk/pdbsum/8fr7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fr7 ProSAT]</span></td></tr>
[[Category: Wilson, E]]
</table>
[[Category: Chiu, W]]
== Function ==
[[Category: Singharoy, A]]
[https://www.uniprot.org/uniprot/SPIKE_CVHNL SPIKE_CVHNL] S1 region attaches the virion to the cell membrane by interacting with human ACE2, initiating the infection. Binding to the receptor probably induces conformational changes in the S glycoprotein unmasking the fusion peptide of S2 region and activating membranes fusion. S2 region belongs to the class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes (By similarity).
[[Category: Chen, M]]
__TOC__
[[Category: Pintilie, G]]
</StructureSection>
[[Category: Schmid, M.F]]
[[Category: Human coronavirus NL63]]
[[Category: Jin, J]]
[[Category: Large Structures]]
[[Category: Chen M]]
[[Category: Chiu W]]
[[Category: Chmielewski D]]
[[Category: Jin J]]
[[Category: Pintilie G]]
[[Category: Schmid MF]]
[[Category: Singharoy A]]
[[Category: Wilson E]]
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