5vij: Difference between revisions

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<StructureSection load='5vij' size='340' side='right'caption='[[5vij]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='5vij' size='340' side='right'caption='[[5vij]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5vij]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5ddn 5ddn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VIJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VIJ FirstGlance]. <br>
<table><tr><td colspan='2'>[[5vij]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5ddn 5ddn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VIJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VIJ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5DX:5-[(2R)-2-AMINO-2-CARBOXYETHYL]-1-(4-BROMOPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC+ACID'>5DX</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.105&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5vii|5vii]], [[5vih|5vih]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5DX:5-[(2R)-2-AMINO-2-CARBOXYETHYL]-1-(4-BROMOPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC+ACID'>5DX</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Grin1, Nmdar1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Grin2a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vij OCA], [https://pdbe.org/5vij PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vij RCSB], [https://www.ebi.ac.uk/pdbsum/5vij PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vij ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vij OCA], [http://pdbe.org/5vij PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vij RCSB], [http://www.ebi.ac.uk/pdbsum/5vij PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vij ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/NMDZ1_RAT NMDZ1_RAT]] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.<ref>PMID:15996549</ref> [[http://www.uniprot.org/uniprot/NMDE1_RAT NMDE1_RAT]] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits.
[https://www.uniprot.org/uniprot/NMDZ1_RAT NMDZ1_RAT] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.<ref>PMID:15996549</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Buffalo rat]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Conti, P]]
[[Category: Rattus norvegicus]]
[[Category: Hansen, K B]]
[[Category: Conti P]]
[[Category: Mou, T C]]
[[Category: Hansen KB]]
[[Category: Pinto, A]]
[[Category: Mou T-C]]
[[Category: Sprang, S R]]
[[Category: Pinto A]]
[[Category: Tamborini, L]]
[[Category: Sprang SR]]
[[Category: Antagonist]]
[[Category: Tamborini L]]
[[Category: Nmda receptor]]
[[Category: Receptor]]
[[Category: Transport protein]]
Retrieved from "https://proteopedia.org/5vij"