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==Crystal structure of thymidylate synthase from Elizabethkingia anophelis NUHP1==
==Crystal structure of thymidylate synthase from Elizabethkingia anophelis NUHP1==
<StructureSection load='6auj' size='340' side='right' caption='[[6auj]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='6auj' size='340' side='right'caption='[[6auj]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6auj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Elizabethkingia_anophelis_nuhp1 Elizabethkingia anophelis nuhp1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AUJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AUJ FirstGlance]. <br>
<table><tr><td colspan='2'>[[6auj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Elizabethkingia_anophelis_NUHP1 Elizabethkingia anophelis NUHP1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AUJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AUJ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M0H:S-(HYDROXYMETHYL)-L-CYSTEINE'>M0H</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M0H:S-(HYDROXYMETHYL)-L-CYSTEINE'>M0H</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">thyA, BD94_0762 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1338011 Elizabethkingia anophelis NUHP1])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6auj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6auj OCA], [https://pdbe.org/6auj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6auj RCSB], [https://www.ebi.ac.uk/pdbsum/6auj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6auj ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6auj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6auj OCA], [http://pdbe.org/6auj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6auj RCSB], [http://www.ebi.ac.uk/pdbsum/6auj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6auj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/A0A077EAN3_9FLAO A0A077EAN3_9FLAO]] Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.[HAMAP-Rule:MF_00008]  
[https://www.uniprot.org/uniprot/A0A077EAN3_9FLAO A0A077EAN3_9FLAO] Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.[HAMAP-Rule:MF_00008]
 
==See Also==
*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Elizabethkingia anophelis nuhp1]]
[[Category: Elizabethkingia anophelis NUHP1]]
[[Category: Thymidylate synthase]]
[[Category: Large Structures]]
[[Category: Structural genomic]]
[[Category: Elizabethkingia anopheli]]
[[Category: Ssgcid]]
[[Category: Transferase]]

Latest revision as of 14:25, 4 October 2023

Crystal structure of thymidylate synthase from Elizabethkingia anophelis NUHP1

6auj, resolution 1.70Å

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