1na3: Difference between revisions
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'''Design of Stable alpha-Helical Arrays from an Idealized TPR Motif''' | '''Design of Stable alpha-Helical Arrays from an Idealized TPR Motif''' | ||
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==About this Structure== | ==About this Structure== | ||
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NA3 OCA]. | |||
==Reference== | ==Reference== | ||
Design of stable alpha-helical arrays from an idealized TPR motif., Main ER, Xiong Y, Cocco MJ, D'Andrea L, Regan L, Structure. 2003 May;11(5):497-508. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12737816 12737816] | Design of stable alpha-helical arrays from an idealized TPR motif., Main ER, Xiong Y, Cocco MJ, D'Andrea L, Regan L, Structure. 2003 May;11(5):497-508. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12737816 12737816] | ||
[[Category: Andrea, L D.]] | [[Category: Andrea, L D.]] | ||
[[Category: Cocco, M.]] | [[Category: Cocco, M.]] | ||
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[[Category: Regan, L.]] | [[Category: Regan, L.]] | ||
[[Category: Xiong, Y.]] | [[Category: Xiong, Y.]] | ||
[[Category: | [[Category: Design]] | ||
[[Category: | [[Category: Tpr]] | ||
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Revision as of 23:16, 2 May 2008
Design of Stable alpha-Helical Arrays from an Idealized TPR Motif
Overview
The tetratricopeptide repeat (TPR) is a 34-amino acid alpha-helical motif that occurs in over 300 different proteins. In the different proteins, three to sixteen or more TPR motifs occur in tandem arrays and function to mediate protein-protein interactions. The binding specificity of each TPR protein is different, although the underlying structural motif is the same. Here we describe a statistical approach to the design of an idealized TPR motif. We present the high-resolution X-ray crystal structures (to 1.55 and 1.6 A) of designed TPR proteins and describe their solution properties and stability. A detailed analysis of these structures provides an understanding of the TPR motif, how it is repeated to give helical arrays with different superhelical twists, and how a very stable framework may be constructed for future functional designs.
About this Structure
Full crystallographic information is available from OCA.
Reference
Design of stable alpha-helical arrays from an idealized TPR motif., Main ER, Xiong Y, Cocco MJ, D'Andrea L, Regan L, Structure. 2003 May;11(5):497-508. PMID:12737816 Page seeded by OCA on Sat May 3 02:16:55 2008
