5l59: Difference between revisions
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<StructureSection load='5l59' size='340' side='right'caption='[[5l59]], [[Resolution|resolution]] 6.00Å' scene=''> | <StructureSection load='5l59' size='340' side='right'caption='[[5l59]], [[Resolution|resolution]] 6.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5l59]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[5l59]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L59 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5L59 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 6Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5l59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l59 OCA], [https://pdbe.org/5l59 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5l59 RCSB], [https://www.ebi.ac.uk/pdbsum/5l59 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5l59 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/PLXA1_MOUSE PLXA1_MOUSE] Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.<ref>PMID:10520994</ref> <ref>PMID:10781943</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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==See Also== | ==See Also== | ||
*[[Plexin|Plexin]] | *[[Plexin 3D structures|Plexin 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: Coles | [[Category: Coles CH]] | ||
[[Category: Gilbert | [[Category: Gilbert RJC]] | ||
[[Category: Janssen | [[Category: Janssen BJC]] | ||
[[Category: Jones | [[Category: Jones EY]] | ||
[[Category: Kaufmann | [[Category: Kaufmann R]] | ||
[[Category: Kong | [[Category: Kong Y]] | ||
[[Category: Malinauskas | [[Category: Malinauskas T]] | ||
[[Category: Ni | [[Category: Ni T]] | ||
[[Category: Padilla-Parra | [[Category: Padilla-Parra S]] | ||
[[Category: Pasterkamp | [[Category: Pasterkamp RJ]] | ||
[[Category: Vangoor | [[Category: Vangoor VR]] | ||
