5l7d: Difference between revisions

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<StructureSection load='5l7d' size='340' side='right'caption='[[5l7d]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<StructureSection load='5l7d' size='340' side='right'caption='[[5l7d]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5l7d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L7D OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5L7D FirstGlance]. <br>
<table><tr><td colspan='2'>[[5l7d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L7D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5L7D FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SMO, SMOH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5l7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l7d OCA], [http://pdbe.org/5l7d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l7d RCSB], [http://www.ebi.ac.uk/pdbsum/5l7d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l7d ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5l7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l7d OCA], [https://pdbe.org/5l7d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5l7d RCSB], [https://www.ebi.ac.uk/pdbsum/5l7d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5l7d ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SMO_HUMAN SMO_HUMAN]] G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.<ref>PMID:19592253</ref>
[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.[https://www.uniprot.org/uniprot/SMO_HUMAN SMO_HUMAN] G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.<ref>PMID:19592253</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Escherichia coli]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Byrne, E F.X]]
[[Category: Byrne EFX]]
[[Category: Covey, D F]]
[[Category: Covey DF]]
[[Category: Hedger, G]]
[[Category: Hedger G]]
[[Category: Luchetti, G]]
[[Category: Luchetti G]]
[[Category: Miller, P S]]
[[Category: Miller PS]]
[[Category: Mydock-McGrane, L]]
[[Category: Mydock-McGrane L]]
[[Category: Nachtergaele, S]]
[[Category: Nachtergaele S]]
[[Category: Newstead, S]]
[[Category: Newstead S]]
[[Category: Rambo, R P]]
[[Category: Rambo RP]]
[[Category: Rohatgi, R]]
[[Category: Rohatgi R]]
[[Category: Sansom, M S.P]]
[[Category: Sansom MSP]]
[[Category: Siebold, C]]
[[Category: Siebold C]]
[[Category: Sircar, R]]
[[Category: Sircar R]]
[[Category: Tully, M D]]
[[Category: Tully MD]]
[[Category: Cholesterol]]
[[Category: G protein coupled receptor]]
[[Category: Hedgehog signaling]]
[[Category: Membrane protein]]
[[Category: Morphogen signaling]]
[[Category: Signaling protein]]
Retrieved from "https://proteopedia.org/5l7d"