6e59: Difference between revisions

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<StructureSection load='6e59' size='340' side='right'caption='[[6e59]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
<StructureSection load='6e59' size='340' side='right'caption='[[6e59]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6e59]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E59 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E59 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6e59]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Pyrococcus_abyssi_GE5 Pyrococcus abyssi GE5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E59 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6E59 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=L76:1-(4-{[(2R,3S)-2-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-3-(4-fluorophenyl)morpholin-4-yl]methyl}-1H-1,2,3-triazol-5-yl)-N,N-dimethylmethanamine'>L76</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TACR1, NK1R, TAC1R ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=L76:1-(4-{[(2R,3S)-2-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-3-(4-fluorophenyl)morpholin-4-yl]methyl}-1H-1,2,3-triazol-5-yl)-N,N-dimethylmethanamine'>L76</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6e59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e59 OCA], [http://pdbe.org/6e59 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e59 RCSB], [http://www.ebi.ac.uk/pdbsum/6e59 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e59 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6e59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e59 OCA], [https://pdbe.org/6e59 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6e59 RCSB], [https://www.ebi.ac.uk/pdbsum/6e59 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6e59 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/NK1R_HUMAN NK1R_HUMAN]] This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.  
[https://www.uniprot.org/uniprot/Q9V2J8_PYRAB Q9V2J8_PYRAB] [https://www.uniprot.org/uniprot/NK1R_HUMAN NK1R_HUMAN] This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Borek, D]]
[[Category: Pyrococcus abyssi GE5]]
[[Category: Chapman, K]]
[[Category: Borek D]]
[[Category: Clark, L]]
[[Category: Chapman K]]
[[Category: Rosenbaum, D M]]
[[Category: Clark L]]
[[Category: Shao, Z]]
[[Category: Rosenbaum DM]]
[[Category: Wang, J]]
[[Category: Shao Z]]
[[Category: Xu, Q]]
[[Category: Wang J]]
[[Category: Yin, J]]
[[Category: Xu Q]]
[[Category: G protein-coupled receptor fusion protein]]
[[Category: Yin J]]
[[Category: Signaling protein]]
Retrieved from "https://proteopedia.org/6e59"