6mv2: Difference between revisions

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<StructureSection load='6mv2' size='340' side='right'caption='[[6mv2]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
<StructureSection load='6mv2' size='340' side='right'caption='[[6mv2]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6mv2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MV2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MV2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6mv2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MV2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MV2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CYB5R4, NCB5OR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cytochrome-b5_reductase Cytochrome-b5 reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.2.2 1.6.2.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mv2 OCA], [https://pdbe.org/6mv2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mv2 RCSB], [https://www.ebi.ac.uk/pdbsum/6mv2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mv2 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mv2 OCA], [http://pdbe.org/6mv2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mv2 RCSB], [http://www.ebi.ac.uk/pdbsum/6mv2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mv2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/NB5R4_HUMAN NB5R4_HUMAN]] NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin.  
[https://www.uniprot.org/uniprot/NB5R4_HUMAN NB5R4_HUMAN] NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Cytochrome-b5 reductase]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Battaile, K P]]
[[Category: Battaile KP]]
[[Category: Benson, D R]]
[[Category: Benson DR]]
[[Category: Cooper, A]]
[[Category: Cooper A]]
[[Category: Gao, P]]
[[Category: Gao P]]
[[Category: Lovell, S]]
[[Category: Lovell S]]
[[Category: Mehzabeen, N]]
[[Category: Mehzabeen N]]
[[Category: Zhu, H]]
[[Category: Zhu H]]
[[Category: Electron transfer]]
[[Category: Endoplasmic reticulum]]
[[Category: Flavoprotein]]
[[Category: Heme]]
[[Category: Iron]]
[[Category: Metal-binding]]
[[Category: Ncb5or]]
[[Category: Oxidoreductase]]
[[Category: Redox]]
Retrieved from "https://proteopedia.org/6mv2"