6o2v: Difference between revisions

<table><tr><td colspan='2'>[[6o2v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O2V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6O2V FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.58&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6o2v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o2v OCA], [https://pdbe.org/6o2v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6o2v RCSB], [https://www.ebi.ac.uk/pdbsum/6o2v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6o2v ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/SARAF_HUMAN SARAF_HUMAN] Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions.<ref>PMID:22464749</ref>  

[[Category: Homo sapiens]]

[[Category: Kimberlin CR]]

[[Category: Minor DL]]