6u54: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
Line 3: Line 3:
<StructureSection load='6u54' size='340' side='right'caption='[[6u54]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='6u54' size='340' side='right'caption='[[6u54]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6u54]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_glama Camelus glama] and [http://en.wikipedia.org/wiki/Eboz5 Eboz5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U54 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6U54 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6u54]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ebola_virus_-_Zaire_(1995) Ebola virus - Zaire (1995)] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U54 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6U54 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=128951 EBOZ5])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6u54 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u54 OCA], [http://pdbe.org/6u54 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u54 RCSB], [http://www.ebi.ac.uk/pdbsum/6u54 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u54 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6u54 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u54 OCA], [https://pdbe.org/6u54 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6u54 RCSB], [https://www.ebi.ac.uk/pdbsum/6u54 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6u54 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/NCAP_EBOZ5 NCAP_EBOZ5]] Oligomerizes into helical capsid to encapsidate the viral genome, protecting it from nucleases and the cellular innate immune response. VP35 binds to and stabilizes monomeric NP, keeping it soluble. Upon virus replication, NP is recruited to bind cooperatively viral genomic RNA and VP35 is released. The encapsidated genomic RNA is termed the nucleocapsid and serves as template for transcription and replication. The nucleocapsid is helical with a pitch of 10.81 NP per turn and a diameter of about 22nm. Each NP binds to six nucleotides of viral genomic RNA, three being exposed to the solvant and three hidden into the nucleocapsid. Recruits also host PPP2R5C phosphatase to dephosphorylate VP30 and thereby promote viral transcription. Upon virion assembly and budding, NP binds to VP24 and possibly host STAU1.[UniProtKB:P18272]  
[https://www.uniprot.org/uniprot/NCAP_EBOZ5 NCAP_EBOZ5] Oligomerizes into helical capsid to encapsidate the viral genome, protecting it from nucleases and the cellular innate immune response. VP35 binds to and stabilizes monomeric NP, keeping it soluble. Upon virus replication, NP is recruited to bind cooperatively viral genomic RNA and VP35 is released. The encapsidated genomic RNA is termed the nucleocapsid and serves as template for transcription and replication. The nucleocapsid is helical with a pitch of 10.81 NP per turn and a diameter of about 22nm. Each NP binds to six nucleotides of viral genomic RNA, three being exposed to the solvant and three hidden into the nucleocapsid. Recruits also host PPP2R5C phosphatase to dephosphorylate VP30 and thereby promote viral transcription. Upon virion assembly and budding, NP binds to VP24 and possibly host STAU1.[UniProtKB:P18272]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 20: Line 20:


==See Also==
==See Also==
*[[Antibody 3D structures|Antibody 3D structures]]
*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
== References ==
== References ==
Line 25: Line 26:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Camelus glama]]
[[Category: Lama glama]]
[[Category: Eboz5]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Hart, P J]]
[[Category: Hart PJ]]
[[Category: Hayhurst, A]]
[[Category: Hayhurst A]]
[[Category: Sherwood, L J]]
[[Category: Sherwood LJ]]
[[Category: Taylor, A B]]
[[Category: Taylor AB]]
[[Category: Antibody]]
[[Category: Ebola]]
[[Category: Filovirus]]
[[Category: Immune system]]
[[Category: Nanobody]]
Retrieved from "https://proteopedia.org/6u54"