6u5l: Difference between revisions

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<StructureSection load='6u5l' size='340' side='right'caption='[[6u5l]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
<StructureSection load='6u5l' size='340' side='right'caption='[[6u5l]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6u5l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U5L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6U5L FirstGlance]. <br>
<table><tr><td colspan='2'>[[6u5l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U5L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6U5L FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3RJ:N~2~-(1H-BENZIMIDAZOL-6-YL)-N~4~-(5-CYCLOBUTYL-1H-PYRAZOL-3-YL)QUINAZOLINE-2,4-DIAMINE'>3RJ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ULK4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3RJ:N~2~-(1H-BENZIMIDAZOL-6-YL)-N~4~-(5-CYCLOBUTYL-1H-PYRAZOL-3-YL)QUINAZOLINE-2,4-DIAMINE'>3RJ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6u5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u5l OCA], [https://pdbe.org/6u5l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6u5l RCSB], [https://www.ebi.ac.uk/pdbsum/6u5l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6u5l ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6u5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u5l OCA], [http://pdbe.org/6u5l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u5l RCSB], [http://www.ebi.ac.uk/pdbsum/6u5l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u5l ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/ULK4_HUMAN ULK4_HUMAN]] Various anomalies in ULK4 gene have been reported for several cases of schizophrenia, schizophrenia plus bipolar disorder and autism. ULK4 gene has been proposed to be a rare susceptibility risk factor for a range of psychiatric diseases including schizophrenia.<ref>PMID:24284070</ref>
[https://www.uniprot.org/uniprot/ULK4_HUMAN ULK4_HUMAN] Various anomalies in ULK4 gene have been reported for several cases of schizophrenia, schizophrenia plus bipolar disorder and autism. ULK4 gene has been proposed to be a rare susceptibility risk factor for a range of psychiatric diseases including schizophrenia.<ref>PMID:24284070</ref>  
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ULK4_HUMAN ULK4_HUMAN]] May be involved in the remodeling of cytoskeletal components, such as alpha-tubulin, and in this way regulates neurite branching and elongation, as well as cell motility.<ref>PMID:24284070</ref>
[https://www.uniprot.org/uniprot/ULK4_HUMAN ULK4_HUMAN] May be involved in the remodeling of cytoskeletal components, such as alpha-tubulin, and in this way regulates neurite branching and elongation, as well as cell motility.<ref>PMID:24284070</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6u5l" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6u5l" style="background-color:#fffaf0;"></div>
==See Also==
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Khamrui S]]
[[Category: Khamrui, S]]
[[Category: Lazarus MB]]
[[Category: Lazarus, M B]]
[[Category: Kinase]]
[[Category: Pseudokinase]]
[[Category: Transferase]]
[[Category: Transferase-transferase inhibitor complex]]
Retrieved from "https://proteopedia.org/6u5l"