6vo8: Difference between revisions

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<StructureSection load='6vo8' size='340' side='right'caption='[[6vo8]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='6vo8' size='340' side='right'caption='[[6vo8]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6vo8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Camje Camje]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VO8 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6VO8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6vo8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Campylobacter_jejuni_subsp._jejuni_NCTC_11168_=_ATCC_700819 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VO8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VO8 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GZ0:[[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-3~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]+[(2~{R},3~{S},4~{S},5~{S},6~{S})-6-[(1~{S})-1,2-bis(oxidanyl)ethyl]-3,4,5-tris(oxidanyl)oxan-2-yl]+hydrogen+phosphate'>GZ0</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6vo6|6vo6]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GZ0:[[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-3~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]+[(2~{R},3~{S},4~{S},5~{S},6~{S})-6-[(1~{S})-1,2-bis(oxidanyl)ethyl]-3,4,5-tris(oxidanyl)oxan-2-yl]+hydrogen+phosphate'>GZ0</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Cj1427c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=192222 CAMJE])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vo8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vo8 OCA], [https://pdbe.org/6vo8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vo8 RCSB], [https://www.ebi.ac.uk/pdbsum/6vo8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vo8 ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-glucose_4-epimerase UDP-glucose 4-epimerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.3.2 5.1.3.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6vo8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vo8 OCA], [http://pdbe.org/6vo8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vo8 RCSB], [http://www.ebi.ac.uk/pdbsum/6vo8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vo8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GMHD_CAMJE GMHD_CAMJE] NAD-dependent dehydrogenase involved in the biosynthesis of heptose moieties with a hydroxyl group at C6 found on the capsular polysaccharide (CPS) of C.jejuni. Catalyzes the initial oxidation of C4 of the GDP-D-glycero-alpha-D-manno-heptose to form GDP-D-glycero-4-keto-alpha-D-lyxo-heptose in the presence of alpha-ketoglutarate required to recycle the NADH nucleotide.<ref>PMID:32168448</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Camje]]
[[Category: Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: UDP-glucose 4-epimerase]]
[[Category: Anderson TK]]
[[Category: Anderson, T K]]
[[Category: Holden HM]]
[[Category: Holden, H M]]
[[Category: Huddleston JP]]
[[Category: Huddleston, J P]]
[[Category: Raushel FM]]
[[Category: Raushel, F M]]
[[Category: Spencer KD]]
[[Category: Spencer, K D]]
[[Category: Thoden JB]]
[[Category: Thoden, J B]]
[[Category: Capsular polysaccharide]]
[[Category: Dehydrogenase]]
[[Category: Isomerase]]
[[Category: Oxidoreductase]]
Retrieved from "https://proteopedia.org/6vo8"