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==Crystal structure of a vFLIP-IKKgamma stapled peptide dimer==
==Crystal structure of a vFLIP-IKKgamma stapled peptide dimer==
<StructureSection load='5lde' size='340' side='right' caption='[[5lde]], [[Resolution|resolution]] 3.38&Aring;' scene=''>
<StructureSection load='5lde' size='340' side='right'caption='[[5lde]], [[Resolution|resolution]] 3.38&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5lde]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Strsg Strsg]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LDE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LDE FirstGlance]. <br>
<table><tr><td colspan='2'>[[5lde]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_8 Human gammaherpesvirus 8] and [https://en.wikipedia.org/wiki/Streptococcus_sp._'group_G' Streptococcus sp. 'group G']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LDE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LDE FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=6ZS:'>6ZS</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.38&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ORF71 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1320 STRSG])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6ZS:L-isovaline'>6ZS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lde FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lde OCA], [http://pdbe.org/5lde PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lde RCSB], [http://www.ebi.ac.uk/pdbsum/5lde PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lde ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lde FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lde OCA], [https://pdbe.org/5lde PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lde RCSB], [https://www.ebi.ac.uk/pdbsum/5lde PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lde ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VFLIP_HHV8P VFLIP_HHV8P] Plays a role in the modulation of host signaling pathways by acting as an activator of both the classic and the alternative NF-kappa-B pathways. Thereby, initiates an important range of cellular processes to promote cell survival, proliferation and protection from apoptosis.<ref>PMID:10523854</ref> <ref>PMID:16311516</ref> <ref>PMID:29698475</ref> [https://www.uniprot.org/uniprot/SPG2_STRSG SPG2_STRSG]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Strsg]]
[[Category: Homo sapiens]]
[[Category: Barrett, T]]
[[Category: Human gammaherpesvirus 8]]
[[Category: Nemo]]
[[Category: Large Structures]]
[[Category: Nf-kb]]
[[Category: Streptococcus sp. 'group G']]
[[Category: Vflip]]
[[Category: Barrett T]]
[[Category: Viral protein]]
Retrieved from "https://proteopedia.org/5lde"