5ldg: Difference between revisions

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<StructureSection load='5ldg' size='340' side='right'caption='[[5ldg]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
<StructureSection load='5ldg' size='340' side='right'caption='[[5ldg]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5ldg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Menpi Menpi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LDG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5LDG FirstGlance]. <br>
<table><tr><td colspan='2'>[[5ldg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mentha_x_piperita Mentha x piperita]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LDG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LDG FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IT9:(-)-ISOPIPERITENONE'>IT9</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/(-)-isopiperitenone_reductase (-)-isopiperitenone reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.82 1.3.1.82] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IT9:(-)-ISOPIPERITENONE'>IT9</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ldg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ldg OCA], [http://pdbe.org/5ldg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ldg RCSB], [http://www.ebi.ac.uk/pdbsum/5ldg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ldg ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ldg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ldg OCA], [https://pdbe.org/5ldg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ldg RCSB], [https://www.ebi.ac.uk/pdbsum/5ldg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ldg ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/IPIPR_MENPI IPIPR_MENPI]] Monoterpene synthase that catalyzes the specific reduction of the 1(2)-double bond of (-)-isopiperitenone to produce (+)-cis-isopulegone. Does not catalyze the reverse reaction. Unable to reduce (+)-pulegone, (+)-cis-isopulegone, (-)-menthone or the 1,2-double bond of (-)-carvone. Able to utilize NADH with 20% the efficiency of NADPH.  
[https://www.uniprot.org/uniprot/IPIPR_MENPI IPIPR_MENPI] Monoterpene synthase that catalyzes the specific reduction of the 1(2)-double bond of (-)-isopiperitenone to produce (+)-cis-isopulegone. Does not catalyze the reverse reaction. Unable to reduce (+)-pulegone, (+)-cis-isopulegone, (-)-menthone or the 1,2-double bond of (-)-carvone. Able to utilize NADH with 20% the efficiency of NADPH.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Menpi]]
[[Category: Mentha x piperita]]
[[Category: Karuppiah, V]]
[[Category: Karuppiah V]]
[[Category: Leys, D]]
[[Category: Leys D]]
[[Category: Scrutton, N S]]
[[Category: Scrutton NS]]
[[Category: Toogood, H S]]
[[Category: Toogood HS]]
[[Category: Isopiperitenone]]
[[Category: Isopulegone]]
[[Category: Oxidoreductase]]
[[Category: Rossmann fold]]