7y53: Difference between revisions
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The | ==The cryo-EM structure of human ERAD retro-translocation complex== | ||
<StructureSection load='7y53' size='340' side='right'caption='[[7y53]], [[Resolution|resolution]] 3.61Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7y53]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Y53 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Y53 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.61Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7y53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7y53 OCA], [https://pdbe.org/7y53 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7y53 RCSB], [https://www.ebi.ac.uk/pdbsum/7y53 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7y53 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/DERL1_HUMAN DERL1_HUMAN] Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.<ref>PMID:15215855</ref> <ref>PMID:15215856</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Cao Y]] | |||
[[Category: Li S]] | |||
[[Category: Li W]] | |||
[[Category: Rao B]] | |||
[[Category: Shen Y]] | |||
[[Category: Wang Q]] | |||
[[Category: Xia Y]] | |||
[[Category: Yao D]] | |||
Latest revision as of 14:03, 18 October 2023
The cryo-EM structure of human ERAD retro-translocation complex
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