8h4m: Difference between revisions
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==Crystal Structure of GTP-bound Irgb6_T95D mutant== | |||
<StructureSection load='8h4m' size='340' side='right'caption='[[8h4m]], [[Resolution|resolution]] 1.68Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8h4m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8H4M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8H4M FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.68Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8h4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8h4m OCA], [https://pdbe.org/8h4m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8h4m RCSB], [https://www.ebi.ac.uk/pdbsum/8h4m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8h4m ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TGTP2_MOUSE TGTP2_MOUSE] Involved in innate cell-autonomous resistance to intracellular pathogens, such as Toxoplasma gondii. During avirulent type II T. gondii infection, recruited to the parasitophorous vacuole (PV) membrane, leading to PV vesiculation and rupture, and subsequent digestion of the parasite within the cytosol (PubMed:19265156, PubMed:24563254). Not recruited to virulent type I T. gondii PV membrane (PubMed:19265156). May confer an antiviral state for vesicular stomatitis virus (PubMed:9725230).<ref>PMID:19265156</ref> <ref>PMID:24563254</ref> <ref>PMID:9725230</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Imasaki T]] | |||
[[Category: Kato T]] | |||
[[Category: Nitta R]] | |||
[[Category: Okuma H]] | |||
[[Category: Saijo-Hamano Y]] | |||
[[Category: Sakai N]] | |||
Latest revision as of 14:06, 18 October 2023
Crystal Structure of GTP-bound Irgb6_T95D mutant
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