8qkt: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 8qkt is ~~ON HOLD~~

==Structure of a nucleosome composed of a palindromic 167-base pair blunt-ended DNA fragment==

~~Authors~~: Ma, Z., ~~Davey~~, C.A.

== Structural highlights ==

<table><tr><td colspan='2'>[[8qkt]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QKT OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=8QKT FirstGlance].

~~Description~~: ~~Structure~~ of a nucleosome ~~composed~~ of ~~a palindromic 167-base pair blunt-ended DNA fragment~~

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.261Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>

[[Category: Davey~~, C.A~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=8qkt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qkt OCA], [https://pdbe.org/8qkt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qkt RCSB], [https://www.ebi.ac.uk/pdbsum/8qkt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qkt ProSAT]</td></tr>

[[Category: Ma, Z]]

</table>

== Function ==

[https://www.uniprot.org/uniprot/H2B1J_HUMAN H2B1J_HUMAN] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Synthetic construct]]

[[Category: Davey CA]]

[[Category: Ma Z]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8qkt is ON HOLD
+==Structure of a nucleosome composed of a palindromic 167-base pair blunt-ended DNA fragment==
+<StructureSection load='8qkt' size='340' side='right'caption='[[8qkt]], [[Resolution|resolution]] 3.26&Aring;' scene=''>
-Authors: Ma, Z., Davey, C.A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8qkt]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QKT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QKT FirstGlance]. <br>
-Description: Structure of a nucleosome composed of a palindromic 167-base pair blunt-ended DNA fragment
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.261&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-[[Category: Davey, C.A]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qkt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qkt OCA], [https://pdbe.org/8qkt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qkt RCSB], [https://www.ebi.ac.uk/pdbsum/8qkt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qkt ProSAT]</span></td></tr>
-[[Category: Ma, Z]]
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/H2B1J_HUMAN H2B1J_HUMAN] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref>   Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Synthetic construct]]
+[[Category: Davey CA]]
+[[Category: Ma Z]]