7r9t: Difference between revisions

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<StructureSection load='7r9t' size='340' side='right'caption='[[7r9t]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='7r9t' size='340' side='right'caption='[[7r9t]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7r9t]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R9T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R9T FirstGlance]. <br>
<table><tr><td colspan='2'>[[7r9t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R9T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R9T FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2TR:6-amino-3-[(1S,3R)-4-chloro-3-hydroxy-1,2-dihydrospiro[cyclopentane-1,3-pyrrolo[2,3-b]pyridin]-5-yl]-2-fluoro-N,N-dimethylbenzamide'>2TR</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2TR:6-amino-3-[(1S,3R)-4-chloro-3-hydroxy-1,2-dihydrospiro[cyclopentane-1,3-pyrrolo[2,3-b]pyridin]-5-yl]-2-fluoro-N,N-dimethylbenzamide'>2TR</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r9t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r9t OCA], [https://pdbe.org/7r9t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r9t RCSB], [https://www.ebi.ac.uk/pdbsum/7r9t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r9t ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r9t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r9t OCA], [https://pdbe.org/7r9t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r9t RCSB], [https://www.ebi.ac.uk/pdbsum/7r9t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r9t ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/M4K1_HUMAN M4K1_HUMAN]] Serine/threonine-protein kinase, which may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate.<ref>PMID:24362026</ref> <ref>PMID:8824585</ref>
[https://www.uniprot.org/uniprot/M4K1_HUMAN M4K1_HUMAN] Serine/threonine-protein kinase, which may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate.<ref>PMID:24362026</ref> <ref>PMID:8824585</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Lehoux I]]
[[Category: Lehoux, I]]
[[Category: Wang W]]
[[Category: Wang, W]]
[[Category: Wu P]]
[[Category: Wu, P]]
[[Category: Inhibitor]]
[[Category: Kinase]]
[[Category: Map4k1]]
[[Category: Transferase-transferase inhibitor complex]]
Retrieved from "https://proteopedia.org/7r9t"