7s53: Difference between revisions

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== Structural highlights ==

<table><tr><td colspan='2'>[[7s53]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7S53 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7S53 FirstGlance]. <br>

<table><tr><td colspan='2'>[[7s53]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Listeria_monocytogenes_EGD-e Listeria monocytogenes EGD-e] and [https://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7S53 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7S53 FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s53 OCA], [https://pdbe.org/7s53 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s53 RCSB], [https://www.ebi.ac.uk/pdbsum/7s53 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s53 ProSAT]</span></td></tr>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s53 OCA], [https://pdbe.org/7s53 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s53 RCSB], [https://www.ebi.ac.uk/pdbsum/7s53 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s53 ProSAT]</span></td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/SRTA_LISMO SRTA_LISMO] Transpeptidase that anchors surface proteins to the cell wall (PubMed:11854224, PubMed:11929538, PubMed:16247833, PubMed:22837151). Recognizes and modifies its substrate by proteolytic cleavage of a C-terminal sorting signal. Following cleavage, a covalent intermediate is formed via a thioester bond between the sortase and its substrate, which is then transferred and covalently attached to the cell wall (Probable). This sortase recognizes a Leu-Pro-x-Thr-Gly (LPXTG) motif, which is cleaved by the sortase between the threonine and glycine residues (PubMed:11929538). Involved in pathogenesis (PubMed:11854224, PubMed:11929538, PubMed:15028680). May regulate the rate of synthesis and/or the stability of a subset of LPXTG proteins (PubMed:22837151). Not involved in cell wall-anchoring of Hbp2 (SvpA) or Hbp1 (PubMed:15028680, PubMed:16247833).<ref>PMID:11854224</ref> <ref>PMID:11929538</ref> <ref>PMID:15028680</ref> <ref>PMID:16247833</ref> <ref>PMID:22837151</ref> <ref>PMID:11929538</ref> [https://www.uniprot.org/uniprot/Q99ZN4_STRP1 Q99ZN4_STRP1]

== Publication Abstract from PubMed ==

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</StructureSection>

[[Category: Large Structures]]

[[Category: ~~Amacher, J F]]~~

[[Category: Listeria monocytogenes EGD-e]]

~~[[Category: Antos, J M]]~~

[[Category: Streptococcus pyogenes]]

~~[[Category: Johnson, D A]]~~

[[Category: Amacher JF]]

~~[[Category: Svendsen, J E]]~~

[[Category: Antos JM]]

~~[[Category: Eight~~-~~stranded beta barrel~~]]

[[Category: Johnson DA]]

[[Category: ~~Housekeeping sortase~~]]

[[Category: Svendsen JE]]

[[Category: ~~Hydrolase~~]]

[[Category: ~~Sortase~~]]

[[Category: ~~Sortase-fold~~]]

[[Category: ~~Surface protein]]~~

~~[[Category: Transpeptidase~~]]

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@@ Line 3: / Line 3: @@
 <StructureSection load='7s53' size='340' side='right'caption='[[7s53]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[7s53]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7S53 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7S53 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[7s53]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Listeria_monocytogenes_EGD-e Listeria monocytogenes EGD-e] and [https://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7S53 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7S53 FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s53 OCA], [https://pdbe.org/7s53 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s53 RCSB], [https://www.ebi.ac.uk/pdbsum/7s53 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s53 ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s53 OCA], [https://pdbe.org/7s53 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s53 RCSB], [https://www.ebi.ac.uk/pdbsum/7s53 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s53 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/SRTA_LISMO SRTA_LISMO] Transpeptidase that anchors surface proteins to the cell wall (PubMed:11854224, PubMed:11929538, PubMed:16247833, PubMed:22837151). Recognizes and modifies its substrate by proteolytic cleavage of a C-terminal sorting signal. Following cleavage, a covalent intermediate is formed via a thioester bond between the sortase and its substrate, which is then transferred and covalently attached to the cell wall (Probable). This sortase recognizes a Leu-Pro-x-Thr-Gly (LPXTG) motif, which is cleaved by the sortase between the threonine and glycine residues (PubMed:11929538). Involved in pathogenesis (PubMed:11854224, PubMed:11929538, PubMed:15028680). May regulate the rate of synthesis and/or the stability of a subset of LPXTG proteins (PubMed:22837151). Not involved in cell wall-anchoring of Hbp2 (SvpA) or Hbp1 (PubMed:15028680, PubMed:16247833).<ref>PMID:11854224</ref> <ref>PMID:11929538</ref> <ref>PMID:15028680</ref> <ref>PMID:16247833</ref> <ref>PMID:22837151</ref> <ref>PMID:11929538</ref> [https://www.uniprot.org/uniprot/Q99ZN4_STRP1 Q99ZN4_STRP1]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 20: / Line 23: @@
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Amacher, J F]]
+[[Category: Listeria monocytogenes EGD-e]]
-[[Category: Antos, J M]]
+[[Category: Streptococcus pyogenes]]
-[[Category: Johnson, D A]]
+[[Category: Amacher JF]]
-[[Category: Svendsen, J E]]
+[[Category: Antos JM]]
-[[Category: Eight-stranded beta barrel]]
+[[Category: Johnson DA]]
-[[Category: Housekeeping sortase]]
+[[Category: Svendsen JE]]
-[[Category: Hydrolase]]
-[[Category: Sortase]]
-[[Category: Sortase-fold]]
-[[Category: Surface protein]]
-[[Category: Transpeptidase]]