7s8g: Difference between revisions
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==== | ==Structure of anti-LASV Fab 25.10C with FNQI mutation== | ||
<StructureSection load='7s8g' size='340' side='right'caption='[[7s8g]]' scene=''> | <StructureSection load='7s8g' size='340' side='right'caption='[[7s8g]], [[Resolution|resolution]] 2.57Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[7s8g]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7S8G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7S8G FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s8g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s8g OCA], [https://pdbe.org/7s8g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s8g RCSB], [https://www.ebi.ac.uk/pdbsum/7s8g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s8g ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.57Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s8g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s8g OCA], [https://pdbe.org/7s8g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s8g RCSB], [https://www.ebi.ac.uk/pdbsum/7s8g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s8g ProSAT]</span></td></tr> | |||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Lassa virus (LASV) is the etiologic agent of Lassa Fever, a hemorrhagic disease that is endemic to West Africa. During LASV infection, LASV glycoprotein (GP) engages with multiple host receptors for cell entry. Neutralizing antibodies against GP are rare and principally target quaternary epitopes displayed only on the metastable, pre-fusion conformation of GP. Currently, the structural features of the neutralizing GPC-A antibody competition group are understudied. Structures of two GPC-A antibodies presented here demonstrate that they bind the side of the pre-fusion GP trimer, bridging the GP1 and GP2 subunits. Complementary biochemical analyses indicate that antibody 25.10C, which is broadly specific, neutralizes by inhibiting binding of the endosomal receptor LAMP1 and also by blocking membrane fusion. The other GPC-A antibody, 36.1F, which is lineage-specific, prevents LAMP1 association only. These data illuminate a site of vulnerability on LASV GP and will guide efforts to elicit broadly reactive therapeutics and vaccines. | |||
Delineating the mechanism of anti-Lassa virus GPC-A neutralizing antibodies.,Enriquez AS, Buck TK, Li H, Norris MJ, Moon-Walker A, Zandonatti MA, Harkins SS, Robinson JE, Branco LM, Garry RF, Saphire EO, Hastie KM Cell Rep. 2022 May 24;39(8):110841. doi: 10.1016/j.celrep.2022.110841. PMID:35613585<ref>PMID:35613585</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 7s8g" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Antibody 3D structures|Antibody 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Enriquez AS]] | ||
[[Category: Hastie KM]] | |||
Latest revision as of 16:46, 18 October 2023
Structure of anti-LASV Fab 25.10C with FNQI mutation
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