7t39: Difference between revisions
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==Co-crystal structure of human PRMT9 in complex with MT221 inhibitor== | ==Co-crystal structure of human PRMT9 in complex with MT221 inhibitor== | ||
<StructureSection load='7t39' size='340' side='right'caption='[[7t39]]' scene=''> | <StructureSection load='7t39' size='340' side='right'caption='[[7t39]], [[Resolution|resolution]] 2.81Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T39 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T39 FirstGlance]. <br> | <table><tr><td colspan='2'>[[7t39]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T39 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T39 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t39 OCA], [https://pdbe.org/7t39 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t39 RCSB], [https://www.ebi.ac.uk/pdbsum/7t39 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t39 ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.81Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EJB:7-[5-S-(4-{[(2-ethylpyridin-3-yl)methyl]amino}butyl)-5-thio-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine'>EJB</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t39 OCA], [https://pdbe.org/7t39 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t39 RCSB], [https://www.ebi.ac.uk/pdbsum/7t39 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t39 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/ANM9_HUMAN ANM9_HUMAN] Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA). Specifically mediates the symmetrical dimethylation of SF3B2. Involved in the regulation of alternative splicing of pre-mRNA (PubMed:25737013, PubMed:25979344).<ref>PMID:25737013</ref> <ref>PMID:25979344</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Arrowsmith CH]] | [[Category: Arrowsmith CH]] | ||
