Retroviral integrase 3D structures

3D Structures of Retroviral Integrase

Updated on 19-October-2023

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• Human spumaretrovirus integrase
  • 3os0, 3os1, 3os2, 3oy9, 3l2q, 3l2r, 4e7j, 4e7k, 4e7l, 5uoq, 5uop, 5no1, 5mmb, 5mma, 5fro, 5frm, 4ztj, 4ztf – intasome – human spumaretrovirus
    
  • 3l2u, 3l2v, 3l2w,3oya, 3oyb, 3oyc, 3oyd, 3oye, 3oyf, 3oyg, 3oyh, 3oyi, 3oyj, 3oyk, 3oyl, 3oym, 3oyn, 4be0, 4be1, 4ztf, 4ztj, 5frm, 5frn, 5fro, 5mma, 5mmb, 5no1, 5uop, 5uoq, 7adu, 7adv – intasome + inhibitor
    
  • 2x6n, 2x6s, 2x74, 2x78, 3dlr - IN catalytic core domain
    
  • 6rny – intasome + nucleosome – Cryo EM
    
  • 3s3m, 4e7h – IN + DNA
    
• Bovine immunodeficiency virus integrase
  • 3kkr, 3kks – IN catalytic core domain – BIV
• Human immunodeficiency virus 1 integrase; Domains – N-terminal zinc-binding 728-773; catalytic core 50-212; C-terminal 219-273; C-terminal DBD 947-997; CCD 1197-1359; intasome 1-288 + DNA
  • 6u8q, 6vdk – intasome – Cryo EM
    
  • 1itg, 4dmn, 5oi5, 5oi3, 5oi2, 6jcg, 6jcf, 6vrg, 8wf7 – IN catalytic core domain
    
  • 3lpt, 3lpu, 3l3u, 1exq, 1b92, 1b9d, 1b9f, 1bi4, 1bhl, 1bl3, 1bis, 1biu, 1biz, 2itg, 3zcm, 5jl4, 6l0c, 6vrg - IN catalytic core domain (mutant) – HIV-1
    
  • 6t6e, 6t6i, 6t6j – IN catalytic C-terminal domain
    
  • 3l3v- IN catalytic core domain (mutant) + sucrose
    
  • 1k6y - IN N-terminal + catalytic core domain
    
  • 1wje, 1wjf - IN N-terminal zinc-binding domain (mutant) – NMR
    
  • 1wja, 1wjb, 1wjc, 1wjd - IN N-terminal zinc-binding domain
    
  • 1ex4 - IN C-terminal DBD + catalytic core domain (mutant)
    
  • 1ihv, 1ihw – IN DBD - NMR
    
  • 1qmc – IN DBD - NMR
    
  • 2b4j, 3av9, 3ava, 3avb, 3avc, 3avf, 3avg, 3avh, 3avi, 3avj, 3avk, 3avl, 3avm, 3avn, 1qs4 - IN CCD domain (mutant) + lens epithelium-derived growth factor
    
  • 8cbt, 8cbv - IN CCD domain + inhibitor
    
  • 3ao5 - IN 765-927 + inhibitor
    
  • 4ahr, 4ahs, 4aht, 4ahu - IN CCD domain (mutant) + inhibitor
    
  • 1hyv, 1hyz, 4cer, 4chp, 4chy, 4o0j, 5krt, 5krs, 5kgx, 5kgw, 6ex9, 6um8, 6vkh, 6vlh, 6vlm, 6vqs, 6vx2, 6w0u, 6w42, 6wc8, 6we7, 7d83, 7ke0, 7l1p, 7l23, 7l2y, 7lqp, 7rq0, 7sia, 7t9h, 7t9o, 7u2u, 7uoq, 7wce, 8bv2, 8cbr – IN catalytic core domain + inhibitor
    
  • 1qs4, 3nf6, 3nf7, 3nf8, 3nf9, 3nfa, 3zsv, 3zsx, 3zt2, 4ceb, 4ces, 4cf9, 4chq, 4cj4, 4cjt, 4cju, 4e1m, 4e1n, 4jlh, 4lh4, 4nyf, 4o55, 4o5b, 4ojr, 4ovl, 4tsx, 5hrs, 5hrr, 5hrp, 5hrn, 5hot, 6eb1, 6eb2, 6lmi, 6lmq, 6ncj, 6nuj, 6vka, 7ue1, 8ct7, 8d3s - IN core domain (mutant) + inhibitor
    
  • 8a1p, 8cbs, 8cbu, 8cta – IN catalytic core+ C-terminal domains + inhibitor
    
  • 8a1q – IN catalytic core+ C-terminal domains + drug
    
  • 5tc2 – IN C terminal
    
  • 5eu7 – IN catalytic core domain + antibody
    
  • 3wne, 3wnh, 4y1d, 4y1c – IN catalytic core domain + peptide
    
  • 8fn7, 8fnd, 8fng, 8fnh, 8fnj, 8fnl, 8fnm, 8fnn, 8fno, 8fnp, 8fnq – IN intasome (mutant) + drug
    
• Human immunodeficiency virus 2 integrase
  • 6qbt – IN catalytic core domain
    
  • 3f9k - IN N-terminal + catalytic core domain + LEDGF IBD – HIV-2
    
  • 1e0e - IN N-terminal – NMR
• Human T-cell leukemia virus
  • 6qbv, 6qbw – IN catalytic core domain
    
  • 6tju – IN C-terminal domain
    
• Moloney murine leukemia virus integrase
  • 3nnq, 4nzg – IN N-terminal – MOMLV
    
  • 2m9u – IN C-terminal domain - NMR
    
  • 7jyz – IN C-terminal domain + hBrd3 - NMR
    
• Maedi Visna virus integrase
  • 3hpg, 3hph – IN N-terminal + catalytic core domain + LEDGF IBD – MVV
    
  • 5t3a – IN
    
  • 5llj – IN C terminal
    
  • 5m0r, 7zpp, 7u32 – intasome – Cryo EM
    
• Simian immunodeficiency virus integrase
  • 1c6v – IN catalytic domain (mutant) + DNA binding domain - SIV
    
  • 6rwl – intasome – Cryo EM
    
  • 6rwo – intasome (mutant) + drug – Cryo EM
    
• Simian T-cell lymphotropic virus
  • 6rwl – intasome + PP2A regulatory subunit – Cryo EM
    
  • 7ouf, 7ouh – intasome (mutant) + B56 + DNA – Cryo EM
    
  • 7oug – intasome (mutant) + B56 + DNA + drug – Cryo EM
    
• Feline immunodeficiency virus integrase
  • 4pa1 - IN catalytic core domain - FIV
    
  • 4mq3 – IN catalytic core domain (mutant)
    
• Mouse mammary tumor virus
  • 5cz1 – IN catalytic domain
    
• Rous sarcoma virus integrase
  • 1c0m, 1c1a – IN fragment (mutant) – RSV
    
  • 1vsk, 1vsl, 3o4q - IN catalytic core domain (mutant)
    
  • 1vsm, 1vsh, 1vsi, 1vsj, 1vsd, 1vse, 1vsf, 3o4n - IN catalytic core domain
    
  • 1a5v, 1a5w, 1a5x - IN catalytic core domain + inhibitor
    
  • 5ejk – intasome + gag-pro-pol polyprotein
    
  • 7ku7, 7kui, 8e14 – intasome – Cryo EM
    
  • 7jn3 – intasome (mutant) + drug – Cryo EM
    
• Avian sarcoma virus integrase
  • 1cxq, 1cxu, 1cz9, 1czb, 1asu, 1asv, 1asw - IN catalytic core domain (mutant) – ASV
• Mouse mammary tumor virus
  • 5cz1 – IN catalytic domain 1487-1648
    
  • 7usf, 7ut1 – IN 1437-1755 + DNA – Cryo EM
    
• Sulfolobus spindle-shaped virus
  • 3vcf – IN C-terminal catalytic domain
    
• Bacterial integrase
  • 3nkh – IN fragment – Staphylococcus aureus MRSA
    
  • 1b69, 1tn9 - EfIN N-terminal DBD + DNA – Enterococcus faecalis – NMR
    
  • 1bb8, 2bb8 - EfIN N-terminal DBD – NMR
    
  • 3nrw – IN/site-specific recombinase N-terminal – Haloarcula marismortui
    
  • 3jtz – IN arm-type binding domain – Yersinia pestis
    
  • 3ju0 – HPI IN arm-type binding domain – Pectobacterium atrosepticum
    
  • 8fti – IN (mutant) + RNA – Planctomycetota bacterium – Cryo EM
    
  • 2kkp – IN SAM-like domain – Moorella thermoacetica – NMR
    
  • 2kkv – IN fragment – Salmonella enterica – NMR
    
  • 2khq - IN fragment – Staphylococcus saprophyticus – NMR
    
  • 2khv, 2kj5 – INT residues 102-199 – Nitrosospira multiformis – NMR
    
  • 2a3v – Rec INTI4+DNA – Vibrio cholera
    
  • 1z19, 1z1b, 1z1g, 1p7d – EpLamInt catalytic core domain+DNA
    
  • 6emy, 6emz, 6en0, 6en1, 6en2 – IN (mutant) + DNA – Enterococcus faecalis
    
• Phage integrase
  • 3bvp – IN N-terminal – Lactococcus phage
    
  • 1aih – HP1 IN catalytic domain – bacteriophage
    
  • 5dor, 5c6k – IN catalytic domain – Enterobacteria phage P2
    
  • 2wcc, 1kjk – λIN DBD+ DNA – Enterobacteria phage λ - NMR
    
  • 2oxo – λIN residues 75-176
    
  • 1ae9 – λIN catalytic core
    
  • 5j0n – λIN + ATTP + ATTB + integration host factor + excisionase - Cryo EM
    
  • 5uae, 5udo – IN coiled-coil domain – Listeria innocua phage
    
• Yeast integrase
  • 1p4e, 1m6x]] – FLP (mutant)+DNA
    
  • 1flo - FLP +DNA
    
  • 7z0h, 7z2z, 7z30, 7z31 – IN + Pol III + DNA – Cryo EM
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Jaime Prilusky