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'''Unreleased structure'''


The entry 8esf is ON HOLD
==Crystal structure of human Nischarin PX and LRR domains with engineered mutations==
 
<StructureSection load='8esf' size='340' side='right'caption='[[8esf]], [[Resolution|resolution]] 2.56&Aring;' scene=''>
Authors: Eldershaw, D.E., Collins, B.M.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8esf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ESF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ESF FirstGlance]. <br>
Description: Crystal structure of human Nischarin PX and LRR domains with engineered mutations
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.56&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
[[Category: Eldershaw, D.E]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8esf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8esf OCA], [https://pdbe.org/8esf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8esf RCSB], [https://www.ebi.ac.uk/pdbsum/8esf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8esf ProSAT]</span></td></tr>
[[Category: Collins, B.M]]
</table>
== Function ==
[https://www.uniprot.org/uniprot/NISCH_HUMAN NISCH_HUMAN] Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension (By similarity). Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons (By similarity). Acts as a modulator of Rac-regulated signal transduction pathways (By similarity). Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity (By similarity). Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation (By similarity). Inhibits also LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation (By similarity). Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells (By similarity). Inhibits lamellipodia formation, when overexpressed (By similarity). Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures.<ref>PMID:10882231</ref> <ref>PMID:12868002</ref> <ref>PMID:15028619</ref> <ref>PMID:15028621</ref> <ref>PMID:15475348</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Collins BM]]
[[Category: Eldershaw DE]]
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