1q91: Difference between revisions

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<StructureSection load='1q91' size='340' side='right'caption='[[1q91]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='1q91' size='340' side='right'caption='[[1q91]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1q91]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q91 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q91 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1q91]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q91 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q91 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DPB:(S)-1-[2-DEOXY-3,5-O-(1-PHOSPHONO)BENZYLIDENE-B-D-THREO-PENTOFURANOSYL]THYMINE'>DPB</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1mh9|1mh9]], [[1q92|1q92]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DPB:(S)-1-[2-DEOXY-3,5-O-(1-PHOSPHONO)BENZYLIDENE-B-D-THREO-PENTOFURANOSYL]THYMINE'>DPB</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/5'-nucleotidase 5'-nucleotidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.5 3.1.3.5] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q91 OCA], [https://pdbe.org/1q91 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q91 RCSB], [https://www.ebi.ac.uk/pdbsum/1q91 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q91 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q91 OCA], [https://pdbe.org/1q91 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q91 RCSB], [https://www.ebi.ac.uk/pdbsum/1q91 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q91 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/NT5M_HUMAN NT5M_HUMAN]] Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP.  
[https://www.uniprot.org/uniprot/NT5M_HUMAN NT5M_HUMAN] Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: 5'-nucleotidase]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Balzarini, J]]
[[Category: Balzarini J]]
[[Category: Bianchi, V]]
[[Category: Bianchi V]]
[[Category: Nordlund, P]]
[[Category: Nordlund P]]
[[Category: Rampazzo, C]]
[[Category: Rampazzo C]]
[[Category: Reichard, P]]
[[Category: Reichard P]]
[[Category: Rinaldo-Matthis, A]]
[[Category: Rinaldo-Matthis A]]
[[Category: Alpha-beta-rossman fold]]
[[Category: Hydrolase]]
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