1veu: Difference between revisions

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<StructureSection load='1veu' size='340' side='right'caption='[[1veu]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
<StructureSection load='1veu' size='340' side='right'caption='[[1veu]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1veu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VEU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VEU FirstGlance]. <br>
<table><tr><td colspan='2'>[[1veu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VEU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VEU FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1vet|1vet]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1veu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1veu OCA], [https://pdbe.org/1veu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1veu RCSB], [https://www.ebi.ac.uk/pdbsum/1veu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1veu ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1veu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1veu OCA], [https://pdbe.org/1veu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1veu RCSB], [https://www.ebi.ac.uk/pdbsum/1veu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1veu ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/LTOR3_MOUSE LTOR3_MOUSE]] As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.<ref>PMID:15263099</ref> <ref>PMID:9733512</ref> [[https://www.uniprot.org/uniprot/LTOR2_MOUSE LTOR2_MOUSE]] As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.<ref>PMID:15263099</ref> 
[https://www.uniprot.org/uniprot/LTOR3_MOUSE LTOR3_MOUSE] As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.<ref>PMID:15263099</ref> <ref>PMID:9733512</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Bartunik, H D]]
[[Category: Bartunik HD]]
[[Category: Bourenkov, G P]]
[[Category: Bourenkov GP]]
[[Category: Clausen, T]]
[[Category: Clausen T]]
[[Category: Eisenhaber, F]]
[[Category: Eisenhaber F]]
[[Category: Hekman, M]]
[[Category: Hekman M]]
[[Category: Huber, L A]]
[[Category: Huber LA]]
[[Category: Kurzbauer, R]]
[[Category: Kurzbauer R]]
[[Category: Maurer-Stroh, S]]
[[Category: Maurer-Stroh S]]
[[Category: Teis, D]]
[[Category: Teis D]]
[[Category: Adaptor]]
[[Category: Profilin]]
[[Category: Scaffold]]
[[Category: Signaling protein-protein binding complex]]
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